Scholarlink

<p>The menin protein, encoded by the Multiple Endocrine Neoplasia Type 1 (MEN1) gene, serves as a critical regulator of cellular processes in human cancers. While menin-targeted therapies are undergoing clinical investigation, a comprehensive pan-cancer analysis of MEN1's diagnostic, prognostic, and immunomodulatory roles remain lacking. Here, we systematically evaluated MEN1 expression patterns and clinical relevance using multi-omics databases and immunohistochemical profiles from the Human Protein Atlas (HPA). MEN1 exhibited ubiquitous expression in normal tissues but was frequently upregulated across multiple malignancies, correlating with adverse survival outcomes. Elevated MEN1 expression demonstrated strong diagnostic utility and positive associations with tumor mutation burden (TMB), suggesting complementary value in cancer detection. Immune landscape analysis revealed significant correlations between MEN1 expression and immune checkpoint genes, as well as immune cell infiltration patterns. Functional characterization implicated MEN1 in activating cell cycle progression, DNA damage response, and oncogenic signaling pathways, as validated through Gene Set Enrichment Analysis (GSEA) and single-sample Gene Set Enrichment Analysis (ssGSEA). These findings position MEN1 as a promising prognostic biomarker and therapeutic target with implications for immuno-oncology and precision medicine.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

An integrated analysis of MEN1 reveals its associations with clinical outcomes, cellular pathways, and the immune microenvironment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月17日

查看全文
  • Hao Li,
  • Xinyu Gong,
  • Yanwei Yao,
  • Ping Bi,
  • Qiang Li,
  • Xiaoru Wang,
  • Jian Peng

摘要

The menin protein, encoded by the Multiple Endocrine Neoplasia Type 1 (MEN1) gene, serves as a critical regulator of cellular processes in human cancers. While menin-targeted therapies are undergoing clinical investigation, a comprehensive pan-cancer analysis of MEN1's diagnostic, prognostic, and immunomodulatory roles remain lacking. Here, we systematically evaluated MEN1 expression patterns and clinical relevance using multi-omics databases and immunohistochemical profiles from the Human Protein Atlas (HPA). MEN1 exhibited ubiquitous expression in normal tissues but was frequently upregulated across multiple malignancies, correlating with adverse survival outcomes. Elevated MEN1 expression demonstrated strong diagnostic utility and positive associations with tumor mutation burden (TMB), suggesting complementary value in cancer detection. Immune landscape analysis revealed significant correlations between MEN1 expression and immune checkpoint genes, as well as immune cell infiltration patterns. Functional characterization implicated MEN1 in activating cell cycle progression, DNA damage response, and oncogenic signaling pathways, as validated through Gene Set Enrichment Analysis (GSEA) and single-sample Gene Set Enrichment Analysis (ssGSEA). These findings position MEN1 as a promising prognostic biomarker and therapeutic target with implications for immuno-oncology and precision medicine.