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Objective <p>This study analyzed the global burden of ovarian cancer in reproductive-aged women (1990–2021) to identify trends, drivers, and project future trends for guiding prevention strategies.</p> Methods <p>Using Global Burden of Disease 2021 data, we analyzed ovarian cancer burden and its association with the Socio-demographic Index (SDI). Trends were evaluated using average annual percentage change and Age-Period-Cohort modeling, with projections to 2036 via ARIMA models.</p> Results <p>In 2021, there were 85,749 new cases and 25,258 deaths globally among reproductive-aged women. The age-standardized rates declined from 1990 to 2021. Projections indicate stable age-standardized incidence and prevalence rates through 2036, but further declines in mortality and DALY rates. Significant regional disparities persist, with the burden decreasing in high-SDI regions but increasing in low- and middle-SDI regions. Disease risk increased after age 35. Successive birth cohorts from the 1990s onward showed a higher baseline risk. Population growth was the primary driver of increasing case numbers. High body mass index (BMI) was the leading risk factor.</p> Conclusions <p>While the global burden of ovarian cancer is declining, substantial regional heterogeneity exists. Tailored strategies focusing on high-risk populations and modifiable factors like high BMI are crucial to mitigate the disease's impact and reduce disparities.</p>

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Analysis of ovarian cancer burden among reproductive-aged women and its association with the socio-demographic index from 1990 to 2021

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月11日

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  • Wangyan Zhong,
  • Yibing Xu,
  • Hang Yuan,
  • Tingting Zhang

摘要

Objective

This study analyzed the global burden of ovarian cancer in reproductive-aged women (1990–2021) to identify trends, drivers, and project future trends for guiding prevention strategies.

Methods

Using Global Burden of Disease 2021 data, we analyzed ovarian cancer burden and its association with the Socio-demographic Index (SDI). Trends were evaluated using average annual percentage change and Age-Period-Cohort modeling, with projections to 2036 via ARIMA models.

Results

In 2021, there were 85,749 new cases and 25,258 deaths globally among reproductive-aged women. The age-standardized rates declined from 1990 to 2021. Projections indicate stable age-standardized incidence and prevalence rates through 2036, but further declines in mortality and DALY rates. Significant regional disparities persist, with the burden decreasing in high-SDI regions but increasing in low- and middle-SDI regions. Disease risk increased after age 35. Successive birth cohorts from the 1990s onward showed a higher baseline risk. Population growth was the primary driver of increasing case numbers. High body mass index (BMI) was the leading risk factor.

Conclusions

While the global burden of ovarian cancer is declining, substantial regional heterogeneity exists. Tailored strategies focusing on high-risk populations and modifiable factors like high BMI are crucial to mitigate the disease's impact and reduce disparities.