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<p>This report explores the evolving management of early esophageal adenocarcinoma (EAC), focusing on the therapeutic balance between endoscopic resection and esophagectomy. It synthesizes recent evidence from international guidelines, surgical and endoscopic series, and predictive modeling studies to clarify lymph-node metastasis (LNM) risk, evaluate current staging limitations, and discuss future directions in treatment stratification and personalized care.</p>

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Evolving challenges in the management of early esophageal adenocarcinoma: from clinical staging to molecular insights

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月10日

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  • Lorenzo Giorgi,
  • Giovanni Maria Garbarino,
  • Renato De Martino,
  • Andrea Pansa,
  • Marta Casiraghi,
  • Silvia Basato,
  • Rita Alfieri,
  • Carlo Castoro

摘要

This report explores the evolving management of early esophageal adenocarcinoma (EAC), focusing on the therapeutic balance between endoscopic resection and esophagectomy. It synthesizes recent evidence from international guidelines, surgical and endoscopic series, and predictive modeling studies to clarify lymph-node metastasis (LNM) risk, evaluate current staging limitations, and discuss future directions in treatment stratification and personalized care.