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Aims <p>To analyse the survival prognosis of elderly patients with stage I-III breast cancer and to explore the related clinicopathological influencing factors.</p> Methods <p>Retrospective collection of clinicopathological data from elderly breast cancer patients (aged ≥ 65 years) admitted to Sichuan Cancer Hospital between October 2014 and December 2022. Survival curves were generated using the Kaplan–Meier method and comparisons were made using the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were employed to identify factors independently associated with five-year event-free survival (EFS).</p> Results <p>A total of 319 elderly patients with stage I-III breast cancer were included, with a 5-year overall EFS rate of 82.0%. Univariate analysis revealed significant associations between 5-year EFS and age, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 level, tumour size (T stage), lymph node status (N stage), and the administration of endocrine therapy (all <i>P</i> &lt; 0.05). Multivariate analysis revealed that age, PR status, T stage, N stage, and Ki-67 level were independent prognostic factors for 5-year EFS.</p> Conclusions <p>The results of this study suggest that age, PR status, the Ki-67 index, tumour size, and lymph node metastasis can serve as independent predictors of the 5-year EFS rate in elderly patients with stage I-III breast cancer. Specifically, younger age (≤ 68 years), PR positivity, Ki-67 &lt; 30%, and early T (T1-T2) and N (N0) stages are associated with a more favourable prognosis.</p>

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Survival prognosis and influencing factors in elderly patients with stage I-III breast cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月31日

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  • Yaling Zeng,
  • Purong Zhang,
  • Yuying Wang,
  • Xihui Tu,
  • Di Lu,
  • Huixi Zhong

摘要

Aims

To analyse the survival prognosis of elderly patients with stage I-III breast cancer and to explore the related clinicopathological influencing factors.

Methods

Retrospective collection of clinicopathological data from elderly breast cancer patients (aged ≥ 65 years) admitted to Sichuan Cancer Hospital between October 2014 and December 2022. Survival curves were generated using the Kaplan–Meier method and comparisons were made using the log-rank test. Univariate and multivariate Cox proportional hazards regression analyses were employed to identify factors independently associated with five-year event-free survival (EFS).

Results

A total of 319 elderly patients with stage I-III breast cancer were included, with a 5-year overall EFS rate of 82.0%. Univariate analysis revealed significant associations between 5-year EFS and age, histological grade, estrogen receptor (ER) status, progesterone receptor (PR) status, Ki-67 level, tumour size (T stage), lymph node status (N stage), and the administration of endocrine therapy (all P < 0.05). Multivariate analysis revealed that age, PR status, T stage, N stage, and Ki-67 level were independent prognostic factors for 5-year EFS.

Conclusions

The results of this study suggest that age, PR status, the Ki-67 index, tumour size, and lymph node metastasis can serve as independent predictors of the 5-year EFS rate in elderly patients with stage I-III breast cancer. Specifically, younger age (≤ 68 years), PR positivity, Ki-67 < 30%, and early T (T1-T2) and N (N0) stages are associated with a more favourable prognosis.