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Background <p>The lymphocyte-to-monocyte ratio (LMR) has been previously analyzed for its value in forecasting prognostic outcomes in patients with small cell lung cancer (SCLC); however, the findings remain conflicting. Therefore, we performed this meta-analysis to identify LMR’s precise role of the LMR in predicting the prognosis of SCLC.</p> Methods <p>We searched PubMed, Embase, Web of Science, and the Cochrane Library until April 10, 2025, and evaluated function of LMR in forecasting SCLC prognosis by determining aggregated hazard ratios (HRs) and 95% confidence intervals (CIs).</p> Results <p>Nine articles involving 1701 cases included in the present study. As revealed by our pooled data, decreased LMR showed close relation to poor overall survival (OS) (HR = 1.49, 95% CI = 1.16–1.91, <i>p</i> = 0.002) and inferior progression-free survival (PFS) (HR = 1.77, 95% CI = 1.16–2.70, <i>p</i> &lt; 0.001) in SCLC. As indicated by subgroup analysis, prominent prognostic value of the LMR for OS remained unaffected by sample size, study center, or threshold point (<i>p</i> &lt; 0.05), and that for PFS remained unaffected by country (<i>p</i> &lt; 0.05). The stability of the results was also verified using sensitivity and publication-bias analyses.</p> Conclusion <p>According to our findings, LMR is markedly related to dismal OS and inferior PFS of patients with SCLC. Thus, LMR can serve as a candidate prognostic marker for SCLC.</p>

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Prognostic value of lymphocyte-to-monocyte ratio in patients with small cell lung cancer: a meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月14日

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  • Fan Yang,
  • Zhaofeng Wang,
  • Minming Wang

摘要

Background

The lymphocyte-to-monocyte ratio (LMR) has been previously analyzed for its value in forecasting prognostic outcomes in patients with small cell lung cancer (SCLC); however, the findings remain conflicting. Therefore, we performed this meta-analysis to identify LMR’s precise role of the LMR in predicting the prognosis of SCLC.

Methods

We searched PubMed, Embase, Web of Science, and the Cochrane Library until April 10, 2025, and evaluated function of LMR in forecasting SCLC prognosis by determining aggregated hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

Nine articles involving 1701 cases included in the present study. As revealed by our pooled data, decreased LMR showed close relation to poor overall survival (OS) (HR = 1.49, 95% CI = 1.16–1.91, p = 0.002) and inferior progression-free survival (PFS) (HR = 1.77, 95% CI = 1.16–2.70, p < 0.001) in SCLC. As indicated by subgroup analysis, prominent prognostic value of the LMR for OS remained unaffected by sample size, study center, or threshold point (p < 0.05), and that for PFS remained unaffected by country (p < 0.05). The stability of the results was also verified using sensitivity and publication-bias analyses.

Conclusion

According to our findings, LMR is markedly related to dismal OS and inferior PFS of patients with SCLC. Thus, LMR can serve as a candidate prognostic marker for SCLC.