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Background <p>Fibrinogen-to-albumin ratio (FAR) has been widely examined for its prognostic value in esophageal cancer (EC), although findings across studies have been inconsistent. This meta-analysis aimed to assess the predictive role of FAR in EC.</p> Methods <p>A comprehensive search was conducted across Web of Science, Embase, PubMed, and Cochrane Library. The prognostic value of FAR in EC was assessed by pooling hazard ratios (HRs) and 95% confidence intervals (CIs). Additionally, the correlation between FAR and clinicopathological features of EC was evaluated using pooled odds ratios (ORs) and 95%CIs.</p> Results <p>A total of six studies involving 2,616 patients were included. The analysis revealed that a high FAR was significantly associated with poor overall survival (OS) in EC (HR = 1.98, 95%CI = 1.48–2.65, <i>p</i> &lt; 0.001). Furthermore, elevated FAR correlated significantly with male sex (OR = 1.38, 95%CI = 1.09–1.74, <i>p</i> = 0.007), T3–T4 stages (OR = 2.36, 95%CI = 1.93–2.87, <i>p</i> &lt; 0.001), N1–N3 stages (OR = 1.58, 95%CI = 1.32–1.91, <i>p</i> &lt; 0.001), TNM III–IV stages (OR = 2.68, 95%CI = 1.52–4.73, <i>p</i> = 0.001), and tumor length &gt; 3&#xa0;cm (OR = 2.36, 95%CI = 1.15–4.87, <i>p</i> = 0.020). However, FAR showed no significant association with age (OR = 0.87, 95%CI = 0.48–1.60, <i>p</i> = 0.660), tumor location (OR = 0.98, 95%CI = 0.77–1.25, <i>p</i> = 0.886), or tumor differentiation (OR = 1.09, 95%CI = 0.76–1.56, <i>p</i> = 0.634).</p> Conclusion <p>This meta-analysis highlights that an elevated FAR is a strong prognostic indicator of poor OS in patients with EC. Moreover, high FAR is significantly associated with clinical features indicative of tumor progression and metastasis.</p>

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Prognostic and clinicopathological value of fibrinogen-to-albumin ratio in patients with esophageal cancer: a meta-analysis

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  • 发表日期：

    2025年6月23日

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  • Ye Liu,
  • Xiaodi Li,
  • Xiaoli Gao,
  • Xiaoling Jin

摘要

Background

Fibrinogen-to-albumin ratio (FAR) has been widely examined for its prognostic value in esophageal cancer (EC), although findings across studies have been inconsistent. This meta-analysis aimed to assess the predictive role of FAR in EC.

Methods

A comprehensive search was conducted across Web of Science, Embase, PubMed, and Cochrane Library. The prognostic value of FAR in EC was assessed by pooling hazard ratios (HRs) and 95% confidence intervals (CIs). Additionally, the correlation between FAR and clinicopathological features of EC was evaluated using pooled odds ratios (ORs) and 95%CIs.

Results

A total of six studies involving 2,616 patients were included. The analysis revealed that a high FAR was significantly associated with poor overall survival (OS) in EC (HR = 1.98, 95%CI = 1.48–2.65, p < 0.001). Furthermore, elevated FAR correlated significantly with male sex (OR = 1.38, 95%CI = 1.09–1.74, p = 0.007), T3–T4 stages (OR = 2.36, 95%CI = 1.93–2.87, p < 0.001), N1–N3 stages (OR = 1.58, 95%CI = 1.32–1.91, p < 0.001), TNM III–IV stages (OR = 2.68, 95%CI = 1.52–4.73, p = 0.001), and tumor length > 3 cm (OR = 2.36, 95%CI = 1.15–4.87, p = 0.020). However, FAR showed no significant association with age (OR = 0.87, 95%CI = 0.48–1.60, p = 0.660), tumor location (OR = 0.98, 95%CI = 0.77–1.25, p = 0.886), or tumor differentiation (OR = 1.09, 95%CI = 0.76–1.56, p = 0.634).

Conclusion

This meta-analysis highlights that an elevated FAR is a strong prognostic indicator of poor OS in patients with EC. Moreover, high FAR is significantly associated with clinical features indicative of tumor progression and metastasis.