Background <p>Oral squamous cell carcinoma (OSCC) is the sixth most common cancer globally. Patient survival varies depending on tumour stage and oral cavity subsites. Buccal mucosa neoplasia is rare and burdened by worse prognosis than other oral subsites, showing a high rate of loco-regional relapses within six months after treatment. According to NCCN guidelines, the gold standard treatment is radical surgery. In the oral cavity, the buccal mucosa subsite lacks anatomical barriers opposing neoplastic growth. At this level, the tumour cells could hypothetically spread along the fibres of the platysma muscle or the lymphatic networks of the peri-facial vessels without encountering any resistance. Due to the aggressive locoregional spread, radical surgery is mandatory to improve patient survival.</p> Methods <p>This technical note describes the cheek compartmental surgical approach step by step. For intermediate-advanced stage cancer, the surgery should include the resection of the tumour with adequate free margins, the dissection of neck lymph nodes and the lymphatic network with the structures between the tumour (T) and the neck (N), the so-called “T-N tract”. The buccal mucosa compartment may be defined as a three-dimensional space between the oral cavity mucosa, the vessel plane, and the lymph nodes of the neck (levels I-IV). These structures, connected by the platysma muscle and the facial vessels, may be considered the T-N tract of the mucosal cheek compartment.</p> Results <p>By removing all the possible pathways of tumour spread via compartmental surgery (<i>en-bloc</i> resection of the tumour with T-N tract and lymphatic network and lymph nodes) for buccal mucosa cancers, one could provide better locoregional control of disease in intermediate-advanced stages.</p> Conclusion <p>This surgical technique may enable a more accurate control of the surgical margins, especially the deep margins.</p>