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Background <p>Liver cirrhosis (LC) significantly impairs health-related quality of life (HR-QoL) due to physical, psychological, and nutritional challenges. Despite its growing burden in India, limited evidence exists on how disease severity, alcohol dependence, and malnutrition influence HR-QoL in Indian LC patients.</p> Methods <p>This cross-sectional study included 565 LC patients attending a tertiary care hospital over 30 months. HR-QoL was assessed using SF-36. Disease severity was graded using the Child-Turcotte-Pugh (CTP) score, while nutritional status and alcohol dependence were evaluated using the RFH-NPT and AUDIT tools. Associations were analysed using Pearson’s correlation, ANOVA, and logistic regression.</p> Results <p>The mean age of participants was 42.5 ± 14.9 years; 81.9% were male, and 58.6% resided in rural areas. Malnutrition was present in 80.9% of patients, and 50.6% were alcohol-dependent. Patients with severe liver cirrhosis (CTP Class C) had significantly lower HR-QoL scores across all domains (<i>p</i> &lt; 0.001). Malnutrition was associated with higher odds of severe liver cirrhosis (OR 1.53; 95% CI: 1.27–1.85), and lower physical function scores were also significantly associated with disease severity (OR 0.89; 95% CI: 0.89–0.95). Severe cirrhosis was additionally marked by elevated serum bilirubin and INR levels, and reduced albumin concentrations.</p> Conclusion <p>HR-QoL declines substantially with worsening cirrhosis, especially in malnourished and alcohol-dependent patients. These findings highlight the need for multidisciplinary interventions focusing on nutrition, lifestyle modification, and psychological support to improve outcomes in LC patients.</p>

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Impact of liver cirrhosis on health-related quality of life in Indian patients: interplay of disease severity, alcohol dependence, and malnutrition

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月14日

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  • Anurag Kumar Singh,
  • Sachin Kumar,
  • Sumit Rajotiya,
  • Shivang Mishra,
  • Prashant Nakash,
  • Pusparghya Pal,
  • Sourav Debnath,
  • Mahaveer Singh,
  • Deepak Nathiya,
  • Balvir Singh Tomar

摘要

Background

Liver cirrhosis (LC) significantly impairs health-related quality of life (HR-QoL) due to physical, psychological, and nutritional challenges. Despite its growing burden in India, limited evidence exists on how disease severity, alcohol dependence, and malnutrition influence HR-QoL in Indian LC patients.

Methods

This cross-sectional study included 565 LC patients attending a tertiary care hospital over 30 months. HR-QoL was assessed using SF-36. Disease severity was graded using the Child-Turcotte-Pugh (CTP) score, while nutritional status and alcohol dependence were evaluated using the RFH-NPT and AUDIT tools. Associations were analysed using Pearson’s correlation, ANOVA, and logistic regression.

Results

The mean age of participants was 42.5 ± 14.9 years; 81.9% were male, and 58.6% resided in rural areas. Malnutrition was present in 80.9% of patients, and 50.6% were alcohol-dependent. Patients with severe liver cirrhosis (CTP Class C) had significantly lower HR-QoL scores across all domains (p < 0.001). Malnutrition was associated with higher odds of severe liver cirrhosis (OR 1.53; 95% CI: 1.27–1.85), and lower physical function scores were also significantly associated with disease severity (OR 0.89; 95% CI: 0.89–0.95). Severe cirrhosis was additionally marked by elevated serum bilirubin and INR levels, and reduced albumin concentrations.

Conclusion

HR-QoL declines substantially with worsening cirrhosis, especially in malnourished and alcohol-dependent patients. These findings highlight the need for multidisciplinary interventions focusing on nutrition, lifestyle modification, and psychological support to improve outcomes in LC patients.