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<p>Long-term obesity treatment remains challenging due to high costs, adverse drug effects, and invasive surgical procedures. Here, we develop an adipocyte-targeted manganese-nucleic acid framework (MNF) with superoxide dismutase (SOD)-like activity. The MNF and allicin are co-encapsulated into a silk fibroin-sulfobutylether-β-cyclodextrin (SFSC) microneedle patch, enabling minimally invasive transdermal delivery specifically to subcutaneous adipose tissue. The combination of MNF and allicin exhibits synergistic effects in alleviating oxidative stress, reducing lipid accumulation, and suppressing M1 macrophage polarization and inflammation. Notably, treatment with MNF was observed to increase intracellular NAD⁺ levels, while allicin upregulates the SIRT1 signaling pathway. This cooperative action appears to engage the NAD⁺-SIRT1 axis, promoting a phenotypic shift of white adipocytes towards beige adipocytes. Collectively, this microneedle-based delivery system, which promotes a beige-like adipocyte phenotype through dual modulation, presents a promising strategy for long-term obesity management.</p> Graphical Abstract <p></p>

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Synergistic promotion of white-to-beige adipocyte transition by manganese-nucleic acid framework and allicin for alleviating obesity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年8月1日

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  • Teng Wang,
  • Bingxin Huangfu,
  • Shurong He,
  • Fengyi Han,
  • Jiayi Gao,
  • Jinru Chen,
  • Wentao Xu,
  • Kunlun Huang,
  • Xiaoyun He

摘要

Long-term obesity treatment remains challenging due to high costs, adverse drug effects, and invasive surgical procedures. Here, we develop an adipocyte-targeted manganese-nucleic acid framework (MNF) with superoxide dismutase (SOD)-like activity. The MNF and allicin are co-encapsulated into a silk fibroin-sulfobutylether-β-cyclodextrin (SFSC) microneedle patch, enabling minimally invasive transdermal delivery specifically to subcutaneous adipose tissue. The combination of MNF and allicin exhibits synergistic effects in alleviating oxidative stress, reducing lipid accumulation, and suppressing M1 macrophage polarization and inflammation. Notably, treatment with MNF was observed to increase intracellular NAD⁺ levels, while allicin upregulates the SIRT1 signaling pathway. This cooperative action appears to engage the NAD⁺-SIRT1 axis, promoting a phenotypic shift of white adipocytes towards beige adipocytes. Collectively, this microneedle-based delivery system, which promotes a beige-like adipocyte phenotype through dual modulation, presents a promising strategy for long-term obesity management.

Graphical Abstract