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<p>Bone defects caused by aging and trauma present significant clinical challenges, driving intense research into bone regeneration strategies. Cellular behaviour during bone repair is critically regulated by the sustainable biophysical cues of the bone niche, particularly topography and electrical signals. Recent advances in biomaterial engineering now enable the precise modulation of these microenvironmental factors—through tuneable topographical and electroactive interfaces—to promote osteogenesis. This review examines emerging evidence on the individual and synergistic roles of surface topography and electrical stimulation in bone regeneration, highlighting their potential as non-pharmacological therapeutic approaches.</p> Graphical Abstract <p></p>

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Advances in osteogenic niche engineering: integrating topography and electrical cues for bone repair and regeneration

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月1日

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  • Jingyan Huang,
  • Dongheng Lu,
  • Yixuan Liu,
  • Taras Vladimirovich Furtsev,
  • Peng Yu,
  • Chenye Hou,
  • Xiaoshuang Wang,
  • Weichang Li,
  • Yan Wang

摘要

Bone defects caused by aging and trauma present significant clinical challenges, driving intense research into bone regeneration strategies. Cellular behaviour during bone repair is critically regulated by the sustainable biophysical cues of the bone niche, particularly topography and electrical signals. Recent advances in biomaterial engineering now enable the precise modulation of these microenvironmental factors—through tuneable topographical and electroactive interfaces—to promote osteogenesis. This review examines emerging evidence on the individual and synergistic roles of surface topography and electrical stimulation in bone regeneration, highlighting their potential as non-pharmacological therapeutic approaches.

Graphical Abstract