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<p>Infected diabetic wounds remain difficult to treat because persistent bacterial reservoirs coexist with a failure to transition from antibacterial defense to regenerative repair. Here, we report a dual-single-atom nanozyme (FeCo-CN) in which atomically dispersed Fe and Co centers are anchored within a nitrogen-coordinated carbon framework, enabling stage-adaptive regulation of the wound microenvironment. During the early infection phase, FeCo-CN exhibits photothermal-enhanced peroxidase-like activity that efficiently reduces extracellular bacteria and promotes macrophage-mediated intracellular bacterial clearance. As the bacterial burden decreases, the material shows superoxide dismutase– and catalase-like activities that alleviate oxidative stress, preserve mitochondrial function, and favor the shift toward reparative immune responses. These coordinated effects support angiogenesis and tissue regeneration. Overall, this work highlights a dual-single-atom nanozyme strategy that integrates infection control with immune transition and tissue repair in infected diabetic wounds.</p> Graphical Abstract <p></p>

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Dual-single-atom nanozyme with stage-adaptive catalytic regulation for infected diabetic wound healing

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月29日

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  • Jian Zhang,
  • Jihai Xu,
  • Chengchun Shen,
  • Peilong Jiang,
  • Heyang Sun,
  • Jian Ruan,
  • Yaopeng Huang,
  • Xin Hong,
  • Shengbing Yang,
  • Hong Chen,
  • Guoping Shi,
  • Xin Wang

摘要

Infected diabetic wounds remain difficult to treat because persistent bacterial reservoirs coexist with a failure to transition from antibacterial defense to regenerative repair. Here, we report a dual-single-atom nanozyme (FeCo-CN) in which atomically dispersed Fe and Co centers are anchored within a nitrogen-coordinated carbon framework, enabling stage-adaptive regulation of the wound microenvironment. During the early infection phase, FeCo-CN exhibits photothermal-enhanced peroxidase-like activity that efficiently reduces extracellular bacteria and promotes macrophage-mediated intracellular bacterial clearance. As the bacterial burden decreases, the material shows superoxide dismutase– and catalase-like activities that alleviate oxidative stress, preserve mitochondrial function, and favor the shift toward reparative immune responses. These coordinated effects support angiogenesis and tissue regeneration. Overall, this work highlights a dual-single-atom nanozyme strategy that integrates infection control with immune transition and tissue repair in infected diabetic wounds.

Graphical Abstract