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<p>Colorectal cancer liver metastasis (CRLM) poses a major challenge in cancer theranostics, in which hepatic stellate cell (HSC) activation participates in fibrosis progression and colorectal cancer (CRC) cell recruitment, catalyzing the formation of fibrosis-concomitant premetastatic niche (PMN). Targeting the crosstalk between activated HSCs (aHSCs) and CRC cells, we develop a bioengineered, mesoporous superparamagnetic iron oxide nanoparticle (mSPIONP)-based theranostic nano-system (mSPIONP-Cur@eCM). Camouflaged with CXC chemokine receptor type 4 (CXCR4)-overexpressing CRC cytomembranes, this nano-system exhibits a dual PMN-targeting function, exerting a homologous recognition to CRC cells and anchors to aHSCs with a high secretion of stromal cell-derived factor-1 (SDF-1). Its mSPIONP-Cur core affords not only T2-weighted magnetic resonance imaging (MRI) but also curcumin (Cur) delivery, initiating liver fibrosis detection and metastasis foci delineation, simultaneously blocking the HSC-CRC cell crosstalk by amplifying Cur’s therapeutic effect. Verified in fibrosis and CRLM models, mSPIONP-Cur@eCM exhibits great potential for suppressing the fibrosis-concomitant PMN and intervening the CRLM progression.</p> Graphical abstract <p></p>

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A magnetic resonance imaging-guided drug delivery system for premetastatic niche theranostics and colorectal cancer liver metastasis intervention

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月26日

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  • Wangping Luo,
  • Xiaoyan Yang,
  • Yining Wang,
  • Jianxia Xu,
  • Yijie Lou,
  • Jiayi Chen,
  • Jue Hou,
  • Xiaojie Wang,
  • Yuanfei Lu,
  • Jin Mao,
  • Guping Tang,
  • Hongzhen Bai,
  • Risheng Yu

摘要

Colorectal cancer liver metastasis (CRLM) poses a major challenge in cancer theranostics, in which hepatic stellate cell (HSC) activation participates in fibrosis progression and colorectal cancer (CRC) cell recruitment, catalyzing the formation of fibrosis-concomitant premetastatic niche (PMN). Targeting the crosstalk between activated HSCs (aHSCs) and CRC cells, we develop a bioengineered, mesoporous superparamagnetic iron oxide nanoparticle (mSPIONP)-based theranostic nano-system (mSPIONP-Cur@eCM). Camouflaged with CXC chemokine receptor type 4 (CXCR4)-overexpressing CRC cytomembranes, this nano-system exhibits a dual PMN-targeting function, exerting a homologous recognition to CRC cells and anchors to aHSCs with a high secretion of stromal cell-derived factor-1 (SDF-1). Its mSPIONP-Cur core affords not only T2-weighted magnetic resonance imaging (MRI) but also curcumin (Cur) delivery, initiating liver fibrosis detection and metastasis foci delineation, simultaneously blocking the HSC-CRC cell crosstalk by amplifying Cur’s therapeutic effect. Verified in fibrosis and CRLM models, mSPIONP-Cur@eCM exhibits great potential for suppressing the fibrosis-concomitant PMN and intervening the CRLM progression.

Graphical abstract