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<p>Persistent infection and dysregulated tissue microenvironment constitute the primary obstacles hindering the healing of infectious diabetic wounds. Herein, we developed an NIR-responsive hydrogel dressing incorporating polyphenol-engineered plant-derived nanovesicles (termed Coronavesicles) via an in-situ deposition strategy, designed to implement sequential photothermal-immunometabolic therapy for infectious diabetic wounds. The coronavesicles within the hydrogel preferentially adhere to bacterial surfaces to deliver localized photothermal therapy (PTT), wherein subsequent heat-triggered rupture releases intrinsic bioactive constituents to enhance antibacterial efficacy. Following bacterial clearance, the released components from coronavesicles synergistically modulate fibroblast proliferation, alleviate oxidative stress, and reverse macrophage-mediated inflammatory immunity. This multi-pronged therapeutic strategy demonstrates desirable treatment outcomes both in vitro and in vivo. This work contributes to the understanding and future development of engineering plant-derived nanovesicles for diabetic wound management.</p> Graphical abstract <p></p>

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Coronavesicle-engineered hydrogel sequential photothermal-immunometabolic therapy reprograms tissue microenvironment for diabetic-infected wounds healing

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月22日

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  • Bodeng Wu,
  • Shan Lin,
  • Qi Xiu,
  • Mingzhen Zhong,
  • Yiyao Huang,
  • Zhenxun Wang,
  • Xiuhua Wu,
  • Jiangang Mei,
  • Shuhan Liu,
  • Liping Liu,
  • Bo Li,
  • Weilun Pan,
  • Lei Zheng

摘要

Persistent infection and dysregulated tissue microenvironment constitute the primary obstacles hindering the healing of infectious diabetic wounds. Herein, we developed an NIR-responsive hydrogel dressing incorporating polyphenol-engineered plant-derived nanovesicles (termed Coronavesicles) via an in-situ deposition strategy, designed to implement sequential photothermal-immunometabolic therapy for infectious diabetic wounds. The coronavesicles within the hydrogel preferentially adhere to bacterial surfaces to deliver localized photothermal therapy (PTT), wherein subsequent heat-triggered rupture releases intrinsic bioactive constituents to enhance antibacterial efficacy. Following bacterial clearance, the released components from coronavesicles synergistically modulate fibroblast proliferation, alleviate oxidative stress, and reverse macrophage-mediated inflammatory immunity. This multi-pronged therapeutic strategy demonstrates desirable treatment outcomes both in vitro and in vivo. This work contributes to the understanding and future development of engineering plant-derived nanovesicles for diabetic wound management.

Graphical abstract