<p>Over the past few decades, research has demonstrated that the progression of cardiovascular diseases is related to platelets, and the associated pathological responses include bleeding and hemostasis, antithrombotic and prothrombotic effects, and immune and inflammatory reactions. Significant platelet-derived biomimetic nanotechnology (PBN) has garnered considerable interest as a drug delivery system due to its excellent biomimetic properties, leading to the enhanced development of innovative therapies. In this review, we have organized the research progress of three types of technologies: platelet receptor-mediated technology, platelet membrane-derived application technology, and artificial platelet-like nanomimetic technology. This review focuses on the use of PBN in cardiovascular diseases, including myocardial ischemia-reperfusion, coronary atherosclerosis, and stenosis, aiming to highlight its potential benefits and uniqueness in this field. This review provides an overview of the main types of current laboratory PBNs and their applications in different cardiovascular diseases. It is meant to stimulate the development of more advanced PBN platforms and provide new ideas for the clinical management of cardiovascular diseases.</p> Graphical abstract <p></p>