<p>The microenvironment and healing process of diabetic wounds are highly complex, necessitating the development of wound dressings that combine excellent biocompatibility, superior antibacterial properties, and immune-regulating capabilities. However, achieving this goal remains a significant challenge. In this study, a multifunctional electrospun dressing (polylactic acid@Ga, PLLA@Ga) was designed and fabricated by integrating sonodynamic therapy with gallium-doped mesoporous bioactive glass (Ga-MBG). Compared to pure PLLA materials, PLLA@Ga exhibited remarkable antibacterial effects in vitro and demonstrated effective anti-infection properties in vivo. These effects are primarily attributed to the release of Ga ions, which competitively replace iron, thereby disrupting iron-dependent bacterial enzymes and ultimately leading to bacterial death. Additionally, in vitro experiments showed that PLLA@Ga could promote macrophage polarization from the M1 to M2 phenotype, effectively modulating the immune microenvironment of diabetic infected wounds. In vivo wound healing experiments further revealed that PLLA@Ga significantly enhanced collagen deposition and angiogenesis, accelerating the healing process of infected diabetic wounds. Thus, the multifunctional electrospun dressing developed in this study holds great potential as a promising candidate for the treatment of diabetic wounds.</p> Graphical abstract <p></p>