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<p>Recent common clinical treatments for implant bacterial infections involve replacing inert implants and using antibiotics. However, these methods remain limited in their effectiveness for pathogen clearance, immune regulation, and osteogenesis. In this study, we developed a Zr-doped heterointerface of SrTiO<sub>3</sub> and Hap (SrTiZrO<sub>3</sub>/Hap) heterojunction coating with single-atom Zr doping and heterogeneous interfaces designed for ultrasound-responsive antimicrobial activity and bone formation. Under ultrasound, the mechanical force exerted by SrTiZrO<sub>3</sub>/Hap enhances its physical puncture and sonodynamic activity, synergizing with the metalloimmunotherapy effect of Zr<sup>4+</sup> for efficient antimicrobial activity. The primary mechanism enhancing sonodynamic activity involves local interfacial polarization from single-atom Zr doping, achieving piezoelectric catalysis in conjunction with electronic polarization from the built-in electric field. SrTiZrO<sub>3</sub>/Hap achieved a 99.3% antibacterial rate against <i>S. aureus</i> and 99.7% against <i>E. coli</i> under ultrasound. Additionally, SrTiZrO<sub>3</sub>/Hap promoted osteogenic differentiation after ultrasound irradiation by activating the PI3K/Akt pathway <i>via</i> its piezoelectric, needle-like topological surface and the release of functional ions, thus accelerating bone repair.</p>

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Single-atom Zr doped heterojunction enhanced piezocatalysis for implant infection therapy through synergistic metal immunotherapy with sonodynamic and physical puncture

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月24日

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  • Xing Zhou,
  • Jingbo Xie,
  • Xingchen Zhou,
  • Tianyou Ma,
  • Yichen Lu,
  • Yiwen Yang,
  • Zhefei Xie,
  • Houfu Ling,
  • Rui Xu,
  • Mo Wu,
  • Jinglei Wang,
  • Weixiang Wang,
  • Derong Kong,
  • Pengchao Xu,
  • Xuan Wan,
  • Hongbo Wu,
  • Peijian Tong,
  • Hanting Xia

摘要

Recent common clinical treatments for implant bacterial infections involve replacing inert implants and using antibiotics. However, these methods remain limited in their effectiveness for pathogen clearance, immune regulation, and osteogenesis. In this study, we developed a Zr-doped heterointerface of SrTiO3 and Hap (SrTiZrO3/Hap) heterojunction coating with single-atom Zr doping and heterogeneous interfaces designed for ultrasound-responsive antimicrobial activity and bone formation. Under ultrasound, the mechanical force exerted by SrTiZrO3/Hap enhances its physical puncture and sonodynamic activity, synergizing with the metalloimmunotherapy effect of Zr4+ for efficient antimicrobial activity. The primary mechanism enhancing sonodynamic activity involves local interfacial polarization from single-atom Zr doping, achieving piezoelectric catalysis in conjunction with electronic polarization from the built-in electric field. SrTiZrO3/Hap achieved a 99.3% antibacterial rate against S. aureus and 99.7% against E. coli under ultrasound. Additionally, SrTiZrO3/Hap promoted osteogenic differentiation after ultrasound irradiation by activating the PI3K/Akt pathway via its piezoelectric, needle-like topological surface and the release of functional ions, thus accelerating bone repair.