Scholarlink

Introduction <p>Effective immunotherapeutic treatment of solid tumors has been greatly challenged by the complex hostile tumor immunosuppressive microenvironment (TIME), which typically involves hypoxia and immunosuppression.</p> Methods <p>Herein, a multifunctional biomimetic gold nano-modulator (denoted as <b>GNR-SNO@MMT</b>) was developed to realize the efficient second near-infrared (NIR-II) photothermal immunotherapy via tumor targeting and deep penetration, vascular normalization and immune reprogramming. NIR-II photothermal agent gold nanorods (GNR) were grafted with thermosensitive S-nitrosothiol (SNO) donors and camouflaged with the tumor-penetrating peptide tLyp-1-modified macrophage membrane (MM) to yield <b>GNR-SNO@MMT</b>.</p> Results <p>The engineered membrane coating increased the capacity for tumor inflammatory tropism and deep penetration, which aided <b>GNR-SNO@MMT</b> in ablating tumors together with NIR-II laser irradiation. Moreover, hyperthermia-stimulated nitric oxide (NO) release in situ acted as a gas immunomodulator to effectively enhance blood perfusion and reprogram the TIME via multiple functions (e.g., decreasing PD-L1, repolarizing tumor-associated macrophages, and revitalizing cytotoxic T cells). Ultimately, the inhibition rate against 4T1 mouse mammary tumor model mediated by <b>GNR-SNO@MMT</b> plus NIR-II laser was 94.7% together with 2.4-fold CD8<sup>+</sup> T cells infiltrated into tumors than that of the untreated counterpart.</p> Conclusions <p>The engineered biomimetic nano-modulator of <b>GNR-SNO@MMT</b> provides an effective and novel photoimmunotherapy candidate against deep-sited solid tumors through immune reconfiguration <i>via</i> NO-involved nanomedicine and external NIR-II laser assistance.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Biomimetic gold nano-modulator for deep-tumor NIR-II photothermal immunotherapy via gaseous microenvironment remodeling strategy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月18日

查看全文
  • Honglin Huang,
  • Zhengxin Xie,
  • Ningxi Li,
  • Li Zeng,
  • Qianyi Zeng,
  • Ziman Yang,
  • Jinyang Shen,
  • Hong Yang,
  • Yiyao Liu,
  • Chunhui Wu

摘要

Introduction

Effective immunotherapeutic treatment of solid tumors has been greatly challenged by the complex hostile tumor immunosuppressive microenvironment (TIME), which typically involves hypoxia and immunosuppression.

Methods

Herein, a multifunctional biomimetic gold nano-modulator (denoted as GNR-SNO@MMT) was developed to realize the efficient second near-infrared (NIR-II) photothermal immunotherapy via tumor targeting and deep penetration, vascular normalization and immune reprogramming. NIR-II photothermal agent gold nanorods (GNR) were grafted with thermosensitive S-nitrosothiol (SNO) donors and camouflaged with the tumor-penetrating peptide tLyp-1-modified macrophage membrane (MM) to yield GNR-SNO@MMT.

Results

The engineered membrane coating increased the capacity for tumor inflammatory tropism and deep penetration, which aided GNR-SNO@MMT in ablating tumors together with NIR-II laser irradiation. Moreover, hyperthermia-stimulated nitric oxide (NO) release in situ acted as a gas immunomodulator to effectively enhance blood perfusion and reprogram the TIME via multiple functions (e.g., decreasing PD-L1, repolarizing tumor-associated macrophages, and revitalizing cytotoxic T cells). Ultimately, the inhibition rate against 4T1 mouse mammary tumor model mediated by GNR-SNO@MMT plus NIR-II laser was 94.7% together with 2.4-fold CD8+ T cells infiltrated into tumors than that of the untreated counterpart.

Conclusions

The engineered biomimetic nano-modulator of GNR-SNO@MMT provides an effective and novel photoimmunotherapy candidate against deep-sited solid tumors through immune reconfiguration via NO-involved nanomedicine and external NIR-II laser assistance.

Graphical abstract