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Purpose <p>Left atrial (LA) volume and strain parameters have been associated with cardiovascular outcomes in several cardiac pathologies, yet their role in predicting major adverse cardiovascular events (MACE) in kidney transplant (KT) recipients has not been explored.</p> Methods <p>We retrospectively reviewed the records of adult KT recipients from our institution (2015–2024). We utilized baseline echocardiograms routinely acquired during KT workup to measure LA volumetrics and strain. MACE was the study’s primary endpoint, defined as cardiovascular death, nonfatal myocardial infarction, stroke, major arrhythmias or heart failure hospitalization. Logistic regression, Kaplan-Meier and Cox proportional hazards regression were performed to evaluate the association between LA parameters and MACE.</p> Results <p>Of 518 patients who underwent kidney transplant, 377 were in sinus rhythm with an acceptable quality echocardiogram (male, 56.7%; mean age 53.7 ± 13.1 years). Over a median follow up duration of 5.3 ± 2.3 years from KT, 82 patients reached the study endpoint. Kaplan-Meier analysis showed significantly lower MACE-free survival in patients with abnormal LA strain. After adjusting for confounding variables in the Cox Proportional Hazards model, of all LA parameters, lower LAScd (HR 0.94, 95% CI 0.89–0.98, <i>p</i> = 0.003), and LASr (HR 0.97, 95% CI 0.94–0.995, <i>p</i> = 0.02) were independently associated with MACE.</p> Conclusion <p>In this retrospective single center study, LA strain parameters particularly LASr and LAScd were independently associated with MACE after KT. LA strain might have a role in risk stratification in this population.</p>

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Association of left atrial volume and function parameters with cardiovascular outcomes following kidney transplantation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月2日

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  • Ava R. DeLonais-Parker,
  • Spencer H. Hobbs,
  • Taylor R. Coffman,
  • Michael F. Kanan,
  • Yanqing Lyu,
  • Elsa J. Treiber,
  • Rushda F. Mansuri,
  • Barbara C. Okeke,
  • Krista L. Lentine,
  • Mina M. Benjamin

摘要

Purpose

Left atrial (LA) volume and strain parameters have been associated with cardiovascular outcomes in several cardiac pathologies, yet their role in predicting major adverse cardiovascular events (MACE) in kidney transplant (KT) recipients has not been explored.

Methods

We retrospectively reviewed the records of adult KT recipients from our institution (2015–2024). We utilized baseline echocardiograms routinely acquired during KT workup to measure LA volumetrics and strain. MACE was the study’s primary endpoint, defined as cardiovascular death, nonfatal myocardial infarction, stroke, major arrhythmias or heart failure hospitalization. Logistic regression, Kaplan-Meier and Cox proportional hazards regression were performed to evaluate the association between LA parameters and MACE.

Results

Of 518 patients who underwent kidney transplant, 377 were in sinus rhythm with an acceptable quality echocardiogram (male, 56.7%; mean age 53.7 ± 13.1 years). Over a median follow up duration of 5.3 ± 2.3 years from KT, 82 patients reached the study endpoint. Kaplan-Meier analysis showed significantly lower MACE-free survival in patients with abnormal LA strain. After adjusting for confounding variables in the Cox Proportional Hazards model, of all LA parameters, lower LAScd (HR 0.94, 95% CI 0.89–0.98, p = 0.003), and LASr (HR 0.97, 95% CI 0.94–0.995, p = 0.02) were independently associated with MACE.

Conclusion

In this retrospective single center study, LA strain parameters particularly LASr and LAScd were independently associated with MACE after KT. LA strain might have a role in risk stratification in this population.