Scholarlink

Background <p>According to the reports of previous studies, dietary fiber has a beneficial effect on controlling serum lipid indices. However, it still remains unclear whether dietary fiber has an influence on mortality among individuals with hyperlipidemia.</p> Methods <p>Our cohort study assessed the association between the daily intake of dietary fiber and both all-cause mortality and cardiovascular disease mortality among adults with hyperlipidemia on the basis of the data of the National Health and Nutrition Examination (1999–2018) participants over 18 years old. For both of the continuous dietary fiber variable and the categorical dietary fiber variable, the Weighted Cox proportional hazards regression models as well as the restricted cubic splines were used to assess this association after categorizing the participants into three groups based on the tertile of the daily intake of dietary fiber.</p> Results <p>For every 10&#xa0;g/day increase in the daily intake of dietary fiber, after multivariable adjustments, the hazard ratio for all-cause mortality was 0.791 (95% confidence interval 0.704–0.890), while the hazard ratio for cardiovascular disease mortality was 0.768 (95% confidence interval 0.609–0.968). Moreover, compared with participants with daily intake of dietary fiber below 11.4&#xa0;g, the hazard ratios for participants with daily intake of dietary fiber above 18.15&#xa0;g were 0.694 (95% confidence interval 0.560–0.860) for all-cause mortality and 0.607 (95% confidence interval 0.399–0.924) for cardiovascular disease mortality. Additionally, the association between the intake of dietary fiber and all-cause mortality remained consistent among most subgroups of adults with hyperlipidemia, such as the subgroup consisting of participants with a TC level ≥ 200&#xa0;mg/dL, the subgroup composed of participants with a TG level ≥ 150&#xa0;mg/dL, the subgroup made up of participants with a LDL-C level ≥ 130&#xa0;mg/dL as well as the subgroup formed by females with a HDL-C level ≤ 50&#xa0;mg/dL and males with a HDL-C level ≤ 40&#xa0;mg/dL.</p> Conclusions <p>For adults with hyperlipidemia, high daily intake of dietary fiber could reduce the risk of both of all-cause mortality and cardiovascular disease mortality.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Dietary fiber intake and mortality among adults with hyperlipidemia : a retrospective cohort analysis from NHANES 1999–2018

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月29日

查看全文
  • Zhenpeng Ye,
  • Mengfei Wei,
  • Zhiruo Wang,
  • Yingfei Zhang,
  • Shea Michaela James,
  • Chenchen Jiang,
  • Chaoming Wu,
  • Xiaomin Shi

摘要

Background

According to the reports of previous studies, dietary fiber has a beneficial effect on controlling serum lipid indices. However, it still remains unclear whether dietary fiber has an influence on mortality among individuals with hyperlipidemia.

Methods

Our cohort study assessed the association between the daily intake of dietary fiber and both all-cause mortality and cardiovascular disease mortality among adults with hyperlipidemia on the basis of the data of the National Health and Nutrition Examination (1999–2018) participants over 18 years old. For both of the continuous dietary fiber variable and the categorical dietary fiber variable, the Weighted Cox proportional hazards regression models as well as the restricted cubic splines were used to assess this association after categorizing the participants into three groups based on the tertile of the daily intake of dietary fiber.

Results

For every 10 g/day increase in the daily intake of dietary fiber, after multivariable adjustments, the hazard ratio for all-cause mortality was 0.791 (95% confidence interval 0.704–0.890), while the hazard ratio for cardiovascular disease mortality was 0.768 (95% confidence interval 0.609–0.968). Moreover, compared with participants with daily intake of dietary fiber below 11.4 g, the hazard ratios for participants with daily intake of dietary fiber above 18.15 g were 0.694 (95% confidence interval 0.560–0.860) for all-cause mortality and 0.607 (95% confidence interval 0.399–0.924) for cardiovascular disease mortality. Additionally, the association between the intake of dietary fiber and all-cause mortality remained consistent among most subgroups of adults with hyperlipidemia, such as the subgroup consisting of participants with a TC level ≥ 200 mg/dL, the subgroup composed of participants with a TG level ≥ 150 mg/dL, the subgroup made up of participants with a LDL-C level ≥ 130 mg/dL as well as the subgroup formed by females with a HDL-C level ≤ 50 mg/dL and males with a HDL-C level ≤ 40 mg/dL.

Conclusions

For adults with hyperlipidemia, high daily intake of dietary fiber could reduce the risk of both of all-cause mortality and cardiovascular disease mortality.