Scholarlink

Objective <p>To characterize the specific pattern of body fat distribution and its association with metabolic syndrome (MetS) among Tibetan adults, an understudied population with distinct high-altitude adaptations, and to identify potential mediating biomarkers in serum lipoprotein profiles.</p> Methods <p>A total of 1480 participants from the Tibetan cohort and the NHANES were included. Principal component analysis and Mantel tests were employed to identify Tibetan-specific body fat indicators. Linear models assessed associations with metabolic syndrome (MetS), and mediation analyses evaluated the indirect effects of serum lipoproteins.</p> Results <p>Tibetans showed distinct trunk and total fat mass compared to other ethnic/racial groups. Trunk fat percentage was identified as a risk factor for MetS (OR = 1.59, 95% CI: 1.27 ~ 1.91, <i>p</i> = 0.004). The triglycerides to total lipids ratio in low density lipoprotein 3 (L3TGP) and triglycerides to high density lipoprotein cholesterol ratio (TGHCR) exhibited significant mediating effect between trunk fat percentage and MetS (L3TGP:β = 1.7 × 10<sup>− 4</sup>g, 95% CI: 4 × 10<sup>− 5</sup>~3.6 × 10<sup>− 4</sup>, <i>p</i>&lt;0.001;TGHCR: β = 1.8 × 10<sup>− 4</sup>g, 95% CI: 4 × 10<sup>− 5</sup>~4.6 × 10<sup>− 4</sup>, <i>p</i>&lt;0.001).</p> Conclusions <p>This study revealed novel evidence for distinct fat distribution in Tibetans, linked to elevated MetS risk. L3TGp and TGHCR were identified as key lipoprotein mediators, supporting the need for environmental- and ethnicity-specific indicators in metabolic risk assessment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Distinct body fat distribution and its association with metabolic syndrome in Tibetan population

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月22日

查看全文
  • Lin Yuan,
  • Haijing Wang,
  • Qingxia Huang,
  • Tiemei Li,
  • Bin Zhang,
  • Huiru Tang,
  • Youfa Wang,
  • Wen Peng

摘要

Objective

To characterize the specific pattern of body fat distribution and its association with metabolic syndrome (MetS) among Tibetan adults, an understudied population with distinct high-altitude adaptations, and to identify potential mediating biomarkers in serum lipoprotein profiles.

Methods

A total of 1480 participants from the Tibetan cohort and the NHANES were included. Principal component analysis and Mantel tests were employed to identify Tibetan-specific body fat indicators. Linear models assessed associations with metabolic syndrome (MetS), and mediation analyses evaluated the indirect effects of serum lipoproteins.

Results

Tibetans showed distinct trunk and total fat mass compared to other ethnic/racial groups. Trunk fat percentage was identified as a risk factor for MetS (OR = 1.59, 95% CI: 1.27 ~ 1.91, p = 0.004). The triglycerides to total lipids ratio in low density lipoprotein 3 (L3TGP) and triglycerides to high density lipoprotein cholesterol ratio (TGHCR) exhibited significant mediating effect between trunk fat percentage and MetS (L3TGP:β = 1.7 × 10− 4g, 95% CI: 4 × 10− 5~3.6 × 10− 4, p<0.001;TGHCR: β = 1.8 × 10− 4g, 95% CI: 4 × 10− 5~4.6 × 10− 4, p<0.001).

Conclusions

This study revealed novel evidence for distinct fat distribution in Tibetans, linked to elevated MetS risk. L3TGp and TGHCR were identified as key lipoprotein mediators, supporting the need for environmental- and ethnicity-specific indicators in metabolic risk assessment.