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Background <p>Prior studies have indicated a notable link between gut health and metabolic syndrome (MetS). The cardiometabolic index (CMI), an innovative indicator of metabolic health, effectively predicts MetS. Bowel movement frequency (BMF) closely reflects gastrointestinal function and is a key sign of gut health. Nonetheless, the relationship between CMI and BMF is still unclear. Our research explores the possible association between these two variables.</p> Methods <p>This study employed 2005 to 2010 National Health and Nutrition Examination Survey data. The CMI for each participant was determined by triglycerides, high-density lipoprotein cholesterol, and the waist-to-hip ratio. Multiple regression, smooth curve fitting, and threshold effect analyses were employed to investigate the association between CMI and BMF. The association’s stability across populations was assessed through subgroup analyses and interaction tests.</p> Results <p>The study included 9,678 participants in total. After controlling for potential confounding variables, those in the uppermost CMI quartile had a 0.69 more increase in BMF than the bottom quartile (β = 0.69, 95% CI: 0.34, 1.03). The trend analyses showed that BMF increased steadily with the advancement of the CMI quartiles (<i>P</i> for trend &lt; 0.0001). Associations between CMI and BMF were shown to be nonlinear through smooth curve fitting and threshold effect analyses. Specifically, when CMI ranged from 4.97 to 11.75, a negative connection was observed (β = -0.78, 95% CI: -1.33, -0.23), while positive associations were identified in other ranges. Subgroup analyses and interaction tests indicated significant CMI and BMF association variations when stratified by depression and age categories (<i>P</i> for interaction &lt; 0.05).</p> Conclusions <p>This research indicates that CMI is generally associated with an increase in BMF. However, when CMI ranges from 4.97 to 11.75, it is associated with a BMF decrease. Notably, the association of CMI and BMF is more potent in young, middle-aged, and depressed people.</p>

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The relationship of cardiometabolic index with bowel movement frequency: an NHANES-based cross-sectional analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月24日

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  • Qianyi Ren,
  • Yanan Wang,
  • Xinhui Han,
  • Qingyi Wang,
  • Guoying Liang

摘要

Background

Prior studies have indicated a notable link between gut health and metabolic syndrome (MetS). The cardiometabolic index (CMI), an innovative indicator of metabolic health, effectively predicts MetS. Bowel movement frequency (BMF) closely reflects gastrointestinal function and is a key sign of gut health. Nonetheless, the relationship between CMI and BMF is still unclear. Our research explores the possible association between these two variables.

Methods

This study employed 2005 to 2010 National Health and Nutrition Examination Survey data. The CMI for each participant was determined by triglycerides, high-density lipoprotein cholesterol, and the waist-to-hip ratio. Multiple regression, smooth curve fitting, and threshold effect analyses were employed to investigate the association between CMI and BMF. The association’s stability across populations was assessed through subgroup analyses and interaction tests.

Results

The study included 9,678 participants in total. After controlling for potential confounding variables, those in the uppermost CMI quartile had a 0.69 more increase in BMF than the bottom quartile (β = 0.69, 95% CI: 0.34, 1.03). The trend analyses showed that BMF increased steadily with the advancement of the CMI quartiles (P for trend < 0.0001). Associations between CMI and BMF were shown to be nonlinear through smooth curve fitting and threshold effect analyses. Specifically, when CMI ranged from 4.97 to 11.75, a negative connection was observed (β = -0.78, 95% CI: -1.33, -0.23), while positive associations were identified in other ranges. Subgroup analyses and interaction tests indicated significant CMI and BMF association variations when stratified by depression and age categories (P for interaction < 0.05).

Conclusions

This research indicates that CMI is generally associated with an increase in BMF. However, when CMI ranges from 4.97 to 11.75, it is associated with a BMF decrease. Notably, the association of CMI and BMF is more potent in young, middle-aged, and depressed people.