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Background <p>Diet and sleep disorders are associated with risks of metabolic diseases such as diabetes. The dietary index for gut microbiota (DI-GM) is a newly proposed index designed to assess dietary quality associated with maintaining a healthy gut microbiota. The authors aim to investigate the separate and joint prognostic effect of DI-GM and sleep disorders on the survival of US population with diabetes and pre-diabetes.</p> Methods <p>Data were from the National Health and Nutrition Examination Survey (NHANES) 2007–2018 at baseline linked to the 2019 National Death Index records.</p> <p>Dietary recall data were collected to calculate the DI-GM and sleep disorders were assessed by self-reported questionnaires. The Cox proportional hazard model were used to evaluate the associations between separate and joint prognostic effects of DI-GM and sleep disorders with mortality outcomes among diabetic and pre-diabetic patients.</p> Results <p>A total of 10718 Participants with diabetes and pre-diabetes were ultimately included in this study (weighted population: 67,232,394, weighted mean age [SE]: 57.0 [0.1] years; weighted female proportion: 51.8%). Among these participants, higher DI-GM was more prevalent in those without sleep disorders.&#xa0;During the median follow-up of 13.3&#xa0;years, 1448 deaths occurred, including 346 participants died from cancer, and 367 died from cardiovascular disease (CVD)..Multivariable models indicated that&#xa0;the joint effects of DI-GM (≥ 6) and no sleep disorders were associated with lower risks for all-cause (HR 0.53, 95% CI: 0.38–0.79) and CVD mortality (HR 0.36, 95% CI: 0.19–0.65).</p> Conclusions <p>In a nationally representative sample of US population with diabetes and pre-diabetes, high DI-GM combined with no sleep disorders was associated with significantly reduced all-cause and CVD mortality risks.</p>

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Joint association of the newly proposed dietary index for gut microbiota and sleep disorders with survival among US adult population with diabetes and pre-diabetes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月18日

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  • Ke Si,
  • Chuanqin Shi,
  • Yajing Huang,
  • Chuanfeng Liu,
  • Jingwei Chi,
  • Lili Xu,
  • Ying Chen,
  • Yangang Wang

摘要

Background

Diet and sleep disorders are associated with risks of metabolic diseases such as diabetes. The dietary index for gut microbiota (DI-GM) is a newly proposed index designed to assess dietary quality associated with maintaining a healthy gut microbiota. The authors aim to investigate the separate and joint prognostic effect of DI-GM and sleep disorders on the survival of US population with diabetes and pre-diabetes.

Methods

Data were from the National Health and Nutrition Examination Survey (NHANES) 2007–2018 at baseline linked to the 2019 National Death Index records.

Dietary recall data were collected to calculate the DI-GM and sleep disorders were assessed by self-reported questionnaires. The Cox proportional hazard model were used to evaluate the associations between separate and joint prognostic effects of DI-GM and sleep disorders with mortality outcomes among diabetic and pre-diabetic patients.

Results

A total of 10718 Participants with diabetes and pre-diabetes were ultimately included in this study (weighted population: 67,232,394, weighted mean age [SE]: 57.0 [0.1] years; weighted female proportion: 51.8%). Among these participants, higher DI-GM was more prevalent in those without sleep disorders. During the median follow-up of 13.3 years, 1448 deaths occurred, including 346 participants died from cancer, and 367 died from cardiovascular disease (CVD)..Multivariable models indicated that the joint effects of DI-GM (≥ 6) and no sleep disorders were associated with lower risks for all-cause (HR 0.53, 95% CI: 0.38–0.79) and CVD mortality (HR 0.36, 95% CI: 0.19–0.65).

Conclusions

In a nationally representative sample of US population with diabetes and pre-diabetes, high DI-GM combined with no sleep disorders was associated with significantly reduced all-cause and CVD mortality risks.