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Background <p>Malaria-associated acute kidney injury (AKI) is a severe complication strongly associated with increased mortality. Early identification of high-risk patients remains difficult, as serum creatinine is a late marker of renal dysfunction. Renal and endothelial injury biomarkers may improve early detection and prognostic stratification.</p> Methods <p>A systematic review was conducted according to PRISMA 2020 guidelines and prospectively registered in PROSPERO (CRD42025642952). A systematic search was performed in PubMed, Scopus, and Web of Science. The search strategy combined the terms (“kidney” AND “biomarkers” AND “malaria”). Included studies were evaluated using the Newcastle–Ottawa Scale (NOS) and the Methodological Index for Non-Randomized Studies (MINORS).</p> Results <p>The combined evaluation of renal and endothelial biomarkers, together with clinical and laboratory parameters, allows improved characterization of AKI in malaria and supports risk stratification. Elevated biomarker levels were consistently associated with increased risk of renal complications and adverse outcomes.</p> Conclusion <p>Renal and endothelial biomarkers may represent promising tools for early detection and monitoring of malaria-associated AKI, with potential to improve risk stratification and clinical management.</p>

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Kidney and endothelial injury biomarkers as predictors of complications and mortality in patients with malaria: a systematic review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月7日

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  • Jarinne Camilo Landim Nasserala,
  • Francisco Naildo Cardoso Leitão,
  • Amanda Vitória Rodrigues dos Santos,
  • Alice Maria Costa Martins,
  • Gdayllon Cavalcante Meneses,
  • Rayane Nascimento de Souza,
  • Geraldo Bezerra da Silva Junior,
  • Elizabeth De Francesco Daher,
  • Mauro José de Deus Morais

摘要

Background

Malaria-associated acute kidney injury (AKI) is a severe complication strongly associated with increased mortality. Early identification of high-risk patients remains difficult, as serum creatinine is a late marker of renal dysfunction. Renal and endothelial injury biomarkers may improve early detection and prognostic stratification.

Methods

A systematic review was conducted according to PRISMA 2020 guidelines and prospectively registered in PROSPERO (CRD42025642952). A systematic search was performed in PubMed, Scopus, and Web of Science. The search strategy combined the terms (“kidney” AND “biomarkers” AND “malaria”). Included studies were evaluated using the Newcastle–Ottawa Scale (NOS) and the Methodological Index for Non-Randomized Studies (MINORS).

Results

The combined evaluation of renal and endothelial biomarkers, together with clinical and laboratory parameters, allows improved characterization of AKI in malaria and supports risk stratification. Elevated biomarker levels were consistently associated with increased risk of renal complications and adverse outcomes.

Conclusion

Renal and endothelial biomarkers may represent promising tools for early detection and monitoring of malaria-associated AKI, with potential to improve risk stratification and clinical management.