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<p>Lung cancer remains the leading cause of cancer-related mortality worldwide, underscoring the urgent need to elucidate its molecular mechanisms to improve treatment and prognosis. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is aberrantly expressed in lung cancer and is closely associated with malignant progression. As a member of the m6A-modified RNA-binding proteins, IGF2BP3 recognizes and binds to m6A-modified RNAs, thereby regulating RNA stability and translation, ultimately influencing cell proliferation, tumorigenesis, and patient outcomes. This review aims to comprehensively explore the molecular mechanisms by which IGF2BP3 contributes to lung cancer development and progression, and to discuss its potential applications in diagnosis, prognostic assessment, and therapeutic strategies.</p>

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The molecular mechanism of IGF2BP3 promoting the malignant progression of lung cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月3日

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  • Chenchen Wu,
  • Yufei Ma,
  • Jiafan Li,
  • Bohan Hai,
  • Yueyang Zhou,
  • Fei Cao,
  • Xiaohong Kang,
  • Xuelian Xu

摘要

Lung cancer remains the leading cause of cancer-related mortality worldwide, underscoring the urgent need to elucidate its molecular mechanisms to improve treatment and prognosis. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is aberrantly expressed in lung cancer and is closely associated with malignant progression. As a member of the m6A-modified RNA-binding proteins, IGF2BP3 recognizes and binds to m6A-modified RNAs, thereby regulating RNA stability and translation, ultimately influencing cell proliferation, tumorigenesis, and patient outcomes. This review aims to comprehensively explore the molecular mechanisms by which IGF2BP3 contributes to lung cancer development and progression, and to discuss its potential applications in diagnosis, prognostic assessment, and therapeutic strategies.