In recent years, researchers have increasingly emphasized the significance of exercise in cancer treatment from the perspective of exercise oncology. Additionally, there has been growing interest in the potential role of medicinal plants in cancer therapy. However, the term “cancer treatment” encompasses numerous critical considerations, among which immunological factors are particularly significant. A recent and noteworthy review by Liu et al. (2025) [1], titled The Interplay of Exercise and Green Tea: A New Road in Cancer Therapy, explored novel perspectives on the roles of exercise and green tea in cancer treatment. While their analysis provides valuable insights, it unfortunately overlooks the crucial aspect of immunological changes, instead focusing primarily on the mechanisms through which physical activity and green tea contribute to cancer therapy. Given the centrality of immunological responses in cancer treatment, it is essential to examine the immunological changes induced by exercise and green tea, as well as their potential interactions. The failure to address these immunological aspects represents a significant research gap. In this article, we aim to bridge this gap by highlighting the immunological changes associated with exercise and green tea, thereby contributing new perspectives to future studies in the field.
