Scholarlink

Background <p>Assess the intake of carbohydrate quality and their association with cardiovascular risk factors among diabetes subtypes.</p> Methods <p>Participants of the German Diabetes Study (GDS) (recent-onset diabetes (n = 487) and 5-years thereafter (n = 209)) were allocated into severe autoimmune diabetes (SAID, 35%), severe insulin-deficient diabetes (SIDD, 3%), severe insulin-resistant diabetes (SIRD, 5%), mild obesity-related diabetes (MOD, 28%), and mild age-related diabetes (MARD, 29%). Dietary glycemic index (GI), glycemic load (GL), and intake of higher- (≥ 55) and low-GI (&lt; 55) foods, dietary fiber, and total sugar were derived from a validated food frequency questionnaire and cross-sectionally associated with cardiovascular risk factors (blood lipids, subclinical inflammation, blood pressure, fatty liver index) using multivariable linear regression analysis for subtypes with prevalences ≥ 10%.</p> Results <p> <?tk 1?>Intake of carbohydrate quality parameters was broadly comparable between the subtypes. Among SAID higher total sugar intake was associated with lower HDL-cholesterol (ß (95% CI) relative change per 1 SD increment: −&#xa0;3.4% (−&#xa0;6.7; −&#xa0;0.1)). No clear associations were seen among MOD. Among MARD, a higher dietary GL and higher-GI carbohydrate intake were associated with higher serum triglycerides (10.9% (2.4; 20.1), 12.4% (3.9; 21.5)) and fatty liver index (absolute change: 0.18 (0.06; 0.31), 0.17 (0.05; 0.28)) and lower HDL-cholesterol (−&#xa0;4.1% (−&#xa0;7.6; −&#xa0;0.4), −&#xa0;4.4% (−&#xa0;7.8; −&#xa0;0.8)), whilst higher intake of low-GI carbohydrates and dietary fiber were associated with lower high-sensitivity C-reactive protein (−&#xa0;16.0% (−&#xa0;25.7; −&#xa0;5.1), −&#xa0;13.9% (−&#xa0;24.2; −&#xa0;2.2)).</p> Conclusions <p>Associations of carbohydrate quality parameters with blood lipids, subclinical inflammation, and fatty liver index differed between diabetes subtypes. However, evidence is too preliminary to derive subtype-specific recommendations.</p> Trial registration <p>Clinicaltrials.gov: NCT01055093.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Associations of carbohydrate quality and cardiovascular risk factors vary among diabetes subtypes

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月6日

查看全文
  • Katharina S. Weber,
  • Sabrina Schlesinger,
  • Janina Goletzke,
  • Klaus Straßburger,
  • Oana-Patricia Zaharia,
  • Sandra Trenkamp,
  • Robert Wagner,
  • Wolfgang Lieb,
  • Anette E. Buyken,
  • Michael Roden,
  • Christian Herder,
  • M. Roden,
  • H. Al-Hasani,
  • B. Belgardt,
  • G. Bönhof,
  • G. Geerling,
  • R. Guthoff,
  • C. Herder,
  • A. Icks,
  • K. Jandeleit-Dahm,
  • J. Kotzka,
  • O. Kuß,
  • E. Lammert,
  • W. Rathmann,
  • S. Schlesinger,
  • V. Schrauwen-Hinderling,
  • J. Szendroedi,
  • S. Trenkamp,
  • R. Wagner

摘要

Background

Assess the intake of carbohydrate quality and their association with cardiovascular risk factors among diabetes subtypes.

Methods

Participants of the German Diabetes Study (GDS) (recent-onset diabetes (n = 487) and 5-years thereafter (n = 209)) were allocated into severe autoimmune diabetes (SAID, 35%), severe insulin-deficient diabetes (SIDD, 3%), severe insulin-resistant diabetes (SIRD, 5%), mild obesity-related diabetes (MOD, 28%), and mild age-related diabetes (MARD, 29%). Dietary glycemic index (GI), glycemic load (GL), and intake of higher- (≥ 55) and low-GI (< 55) foods, dietary fiber, and total sugar were derived from a validated food frequency questionnaire and cross-sectionally associated with cardiovascular risk factors (blood lipids, subclinical inflammation, blood pressure, fatty liver index) using multivariable linear regression analysis for subtypes with prevalences ≥ 10%.

Results

Intake of carbohydrate quality parameters was broadly comparable between the subtypes. Among SAID higher total sugar intake was associated with lower HDL-cholesterol (ß (95% CI) relative change per 1 SD increment: − 3.4% (− 6.7; − 0.1)). No clear associations were seen among MOD. Among MARD, a higher dietary GL and higher-GI carbohydrate intake were associated with higher serum triglycerides (10.9% (2.4; 20.1), 12.4% (3.9; 21.5)) and fatty liver index (absolute change: 0.18 (0.06; 0.31), 0.17 (0.05; 0.28)) and lower HDL-cholesterol (− 4.1% (− 7.6; − 0.4), − 4.4% (− 7.8; − 0.8)), whilst higher intake of low-GI carbohydrates and dietary fiber were associated with lower high-sensitivity C-reactive protein (− 16.0% (− 25.7; − 5.1), − 13.9% (− 24.2; − 2.2)).

Conclusions

Associations of carbohydrate quality parameters with blood lipids, subclinical inflammation, and fatty liver index differed between diabetes subtypes. However, evidence is too preliminary to derive subtype-specific recommendations.

Trial registration

Clinicaltrials.gov: NCT01055093.