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Background <p>Lung cancer is the leading cause of cancer death in the US and worldwide. This study examines regional and state-level trends in lung cancer mortality in the US from 1999 to 2022.</p> Methods <p>Center for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) was used to obtain data on lung cancer mortality in people ages 25 years and older. Age-Adjusted Mortality Rate (AAMR) was calculated along with Annual Percent Change (APC) and Average Annual Percent Change (AAPC).</p> Results <p>In general, the age-adjusted mortality rate (AAMR) for lung cancer declined from 91.4 (95% CI 91.0 to 91.9) in 1999 to 52.0 (95% CI 51.7 to 52.2) in 2022. Throughout the study, the Midwest and South regions consistently exhibited the highest mortality rates. Notably, distinct patterns emerged when analyzing mortality rates by race and gender within each region.</p> Conclusion <p>This study revealed significant variations in lung cancer mortality at both regional and state levels. Recognizing these disparities is essential for healthcare policymakers and researchers to monitor progress in reducing lung cancer deaths and identifying the populations most vulnerable to this disease.</p>

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Regional trends and disparities of lung cancer mortality in the United States, 1999–2022: a retrospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月1日

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  • Taylor Billion,
  • Logan Verheyen,
  • Ali Bin Abdul Jabbar,
  • Noureen Asghar,
  • Mohsin Mirza,
  • Muazzam Mirza,
  • Abubakar Tauseef

摘要

Background

Lung cancer is the leading cause of cancer death in the US and worldwide. This study examines regional and state-level trends in lung cancer mortality in the US from 1999 to 2022.

Methods

Center for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) was used to obtain data on lung cancer mortality in people ages 25 years and older. Age-Adjusted Mortality Rate (AAMR) was calculated along with Annual Percent Change (APC) and Average Annual Percent Change (AAPC).

Results

In general, the age-adjusted mortality rate (AAMR) for lung cancer declined from 91.4 (95% CI 91.0 to 91.9) in 1999 to 52.0 (95% CI 51.7 to 52.2) in 2022. Throughout the study, the Midwest and South regions consistently exhibited the highest mortality rates. Notably, distinct patterns emerged when analyzing mortality rates by race and gender within each region.

Conclusion

This study revealed significant variations in lung cancer mortality at both regional and state levels. Recognizing these disparities is essential for healthcare policymakers and researchers to monitor progress in reducing lung cancer deaths and identifying the populations most vulnerable to this disease.