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Background <p>Trichilemmal carcinoma (TC) is a rare cutaneous appendage malignancy with scarce human cases and very few animal cases have been documented in the available literature, especially in giant pandas.</p> Case presentation <p>A 23-year-old male captive giant panda had 4-week scrotal hyperplasia and ulceration, with a 4.5&#xa0;cm×4&#xa0;cm irregular lesion and neutrophils were elevated. Pathology revealed dermal lobular/cord-like invasive atypical clear cells, squamous nests and outer root sheath cysts. PAS staining was positive. Immunohistochemistry showed Her-2 (+), CK5/6 (++), p63 (++), Ki-67 (+), CD34 (+), and p53 (+), excluding squamous cell carcinoma and trichofolliculoma. Local resection (0.8&#xa0;cm margin) was done under general anesthesia. Postoperative anti-infection led to 2-week wound healing; 3-month follow-up showed no recurrence with normal behavior.</p> Conclusions <p>This first reported giant panda TC with human-like immunophenotype provides evidence for managing rare animal cutaneous appendage tumors.</p>

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Unique occurrence of trichilemmal carcinoma in the scrotal skin of a giant panda: a pathological analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月26日

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  • Chengyao Li,
  • Zongliang Xiong,
  • Shanshan Ling,
  • Yan Zhu,
  • Linhua Deng,
  • Mengfang Yang,
  • Chengdong Wang,
  • Qian Wang,
  • Danyu Chen,
  • Mao Huang,
  • Kao Wang,
  • Desheng Li,
  • Zhengli Chen,
  • Caiwu Li

摘要

Background

Trichilemmal carcinoma (TC) is a rare cutaneous appendage malignancy with scarce human cases and very few animal cases have been documented in the available literature, especially in giant pandas.

Case presentation

A 23-year-old male captive giant panda had 4-week scrotal hyperplasia and ulceration, with a 4.5 cm×4 cm irregular lesion and neutrophils were elevated. Pathology revealed dermal lobular/cord-like invasive atypical clear cells, squamous nests and outer root sheath cysts. PAS staining was positive. Immunohistochemistry showed Her-2 (+), CK5/6 (++), p63 (++), Ki-67 (+), CD34 (+), and p53 (+), excluding squamous cell carcinoma and trichofolliculoma. Local resection (0.8 cm margin) was done under general anesthesia. Postoperative anti-infection led to 2-week wound healing; 3-month follow-up showed no recurrence with normal behavior.

Conclusions

This first reported giant panda TC with human-like immunophenotype provides evidence for managing rare animal cutaneous appendage tumors.