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<p>Yeast culture has been widely used to modulate health and physiological functions in ruminants. However, its regulatory effects on hepatic metabolism remain incompletely understood. This study aimed to investigate the effects of compound yeast culture (CYC) on hepatic metabolic characteristics in lambs using untargeted metabolomics and to explore the underlying regulatory mechanisms. Eighteen weaned lambs were randomly assigned to three groups: a control group (Con) fed a basal total mixed ration (TMR), and two treatment groups supplemented with CYC at 40&#xa0;g/d (Group M) or 50&#xa0;g/d (Group Y) per head. Untargeted metabolomic analysis of lamb liver revealed that antioxidant-related metabolic pathways were significantly upregulated in Group M. In Group Y, in addition to the activation of antioxidant pathways, several energy metabolism–related pathways were downregulated. Biochemical validation further showed that the higher dose of CYC (50&#xa0;g/d per head) exerted a stronger regulatory effect on hepatic antioxidant capacity and energy metabolism. Overall, these findings suggest that CYC may regulate hepatic metabolism through coordinated modulation of antioxidant metabolism and energy utilization, thereby exerting protective metabolic effects on the lamb liver in a dose-dependent manner.</p>

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Feeding compound yeast culture alters hepatic metabolic profiles in weaned lambs: insights into antioxidant enhancement and energy redistribution

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月22日

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  • Yuan Wang,
  • Pengxiang Bai,
  • Puguo Hao,
  • Wenyan Bi,
  • Chenlu Li,
  • Chenxue Zhang,
  • Dacheng Liu,
  • Hui Chen

摘要

Yeast culture has been widely used to modulate health and physiological functions in ruminants. However, its regulatory effects on hepatic metabolism remain incompletely understood. This study aimed to investigate the effects of compound yeast culture (CYC) on hepatic metabolic characteristics in lambs using untargeted metabolomics and to explore the underlying regulatory mechanisms. Eighteen weaned lambs were randomly assigned to three groups: a control group (Con) fed a basal total mixed ration (TMR), and two treatment groups supplemented with CYC at 40 g/d (Group M) or 50 g/d (Group Y) per head. Untargeted metabolomic analysis of lamb liver revealed that antioxidant-related metabolic pathways were significantly upregulated in Group M. In Group Y, in addition to the activation of antioxidant pathways, several energy metabolism–related pathways were downregulated. Biochemical validation further showed that the higher dose of CYC (50 g/d per head) exerted a stronger regulatory effect on hepatic antioxidant capacity and energy metabolism. Overall, these findings suggest that CYC may regulate hepatic metabolism through coordinated modulation of antioxidant metabolism and energy utilization, thereby exerting protective metabolic effects on the lamb liver in a dose-dependent manner.