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Background <p>Here, we describe a case of an intracranial fungal granuloma in an adult, non-castrated female dromedary camel (<i>Camelus dromedarius</i>).</p> Case presentation <p>An 11-year-old female dromedary presented with progressive neurological signs over several weeks. Neurological examination suggested a forebrain lesion, and magnetic resonance imaging (MRI) revealed a mass in the frontal fossa. Owing to poor prognosis, the animal was euthanized. Histopathological examination demonstrated a granulomatous-necrotizing inflammatory process containing fungal structures. Broad-range polymerase chain reaction (PCR) and amplicon sequencing results were consistent with a member of the <i>Aspergillus fumigatus</i> species complex being the causative agent.</p> Conclusions <p>Central nervous system involvement is rare in fungal infections. Intracranial fungal granulomas should be considered as a differential diagnosis in camels presenting with progressive neurological signs and space-occupying intracranial lesions.</p>

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Case report: intracranial fungal granuloma in a dromedary (Camelus dromedarius)

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  • 发表日期：

    2026年3月6日

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  • Meike-Louisa Schmidt,
  • Marlene Sickinger,
  • Volker Rickerts,
  • Ilka McCormick-Smith,
  • Kernt Köhler

摘要

Background

Here, we describe a case of an intracranial fungal granuloma in an adult, non-castrated female dromedary camel (Camelus dromedarius).

Case presentation

An 11-year-old female dromedary presented with progressive neurological signs over several weeks. Neurological examination suggested a forebrain lesion, and magnetic resonance imaging (MRI) revealed a mass in the frontal fossa. Owing to poor prognosis, the animal was euthanized. Histopathological examination demonstrated a granulomatous-necrotizing inflammatory process containing fungal structures. Broad-range polymerase chain reaction (PCR) and amplicon sequencing results were consistent with a member of the Aspergillus fumigatus species complex being the causative agent.

Conclusions

Central nervous system involvement is rare in fungal infections. Intracranial fungal granulomas should be considered as a differential diagnosis in camels presenting with progressive neurological signs and space-occupying intracranial lesions.