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Background <p><i>Klebsiella pneumoniae</i> (<i>K. pneumoniae</i>) is a zoonotic opportunistic pathogen that can cause pneumonia in minks, significantly impacting the mink breeding industry. In this study, a <i>K. pneumoniae</i> strain carrying the <i>mcr-1</i> gene was isolated from mink in Shandong Province, China. To investigate its genetic composition and resistance mechanisms, antimicrobial susceptibility testing and whole-genome sequencing were conducted.</p> Results <p>The results revealed that <i>K. pneumonia</i> strain was ST15, with serotypes KL24 and O1/02V1. Antimicrobial susceptibility testing showed that the strain was multi-drug resistant. The ST15 isolate carried several resistance genes, which correlated with its resistance profile. Two plasmids, classified as IncHI2 and IncR, were identified in the strain. The <i>mcr-1</i> gene was located on the IncHI2 plasmid, which also harbored other resistance genes. Another plasmid was found to carry additional drug resistance genes, contributing to the strain’s broad-spectrum resistance phenotype. Upstream of the <i>mcr-1</i> gene is the ISApl1, which is closely associated with the dissemination of the <i>mcr-1</i> gene in <i>K. pneumoniae</i> strain.</p> Conclusion <p>This study reported the presence of the <i>mcr-1</i> gene in an ST15 <i>K. pneumoniae</i> strain isolated from mink. The findings highlight the role of antibiotic resistance and the riskiness of <i>K. pneumoniae</i> from animals harboring the <i>mcr-1</i> gene.</p>

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Antibiotic resistance profiles and genomic analysis of Klebsiella pneumoniae ST15 with mcr-1 gene isolated from mink in China

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月8日

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  • Na Sun,
  • Yanming Lv,
  • Jingqing Yang,
  • Xingang Zhu,
  • Yuening Cheng,
  • Zhihao San,
  • Li Guo,
  • Lianjun Fu,
  • Baishuang Yin,
  • Qiang Chen

摘要

Background

Klebsiella pneumoniae (K. pneumoniae) is a zoonotic opportunistic pathogen that can cause pneumonia in minks, significantly impacting the mink breeding industry. In this study, a K. pneumoniae strain carrying the mcr-1 gene was isolated from mink in Shandong Province, China. To investigate its genetic composition and resistance mechanisms, antimicrobial susceptibility testing and whole-genome sequencing were conducted.

Results

The results revealed that K. pneumonia strain was ST15, with serotypes KL24 and O1/02V1. Antimicrobial susceptibility testing showed that the strain was multi-drug resistant. The ST15 isolate carried several resistance genes, which correlated with its resistance profile. Two plasmids, classified as IncHI2 and IncR, were identified in the strain. The mcr-1 gene was located on the IncHI2 plasmid, which also harbored other resistance genes. Another plasmid was found to carry additional drug resistance genes, contributing to the strain’s broad-spectrum resistance phenotype. Upstream of the mcr-1 gene is the ISApl1, which is closely associated with the dissemination of the mcr-1 gene in K. pneumoniae strain.

Conclusion

This study reported the presence of the mcr-1 gene in an ST15 K. pneumoniae strain isolated from mink. The findings highlight the role of antibiotic resistance and the riskiness of K. pneumoniae from animals harboring the mcr-1 gene.