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<p>Non-depolarizing neuromuscular blocking agents (NMBAs) are commonly used in human anesthesia but remain uncommon in veterinary medicine. This study evaluated the effects of 0.5&#xa0;mg/kg cisatracurium IV on muscle relaxation, cardiovascular variables and postoperative pain in cats undergoing orthopedic surgery. Twenty-four cats were randomly assigned to a control group (Group C) or a treatment group receiving cisatracurium (Group M) immediately after induction. Neuromuscular function was monitored using a calibrated train-of-four (TOF) device. Postoperative pain was assessed with the short form of the Glasgow Feline Composite Measure Pain Scale (CMPS-Feline). The mean time to suppression of muscle contraction was 2.6 ± 0.8&#xa0;min, with peak suppression (90%) at 3.0 ± 0.7&#xa0;min, a mean duration of 23.3 ± 4.4&#xa0;min, and complete recovery at 27.3 ± 8.6&#xa0;min. Group M required lower sevoflurane concentrations to maintain anesthesia compared to Group C (<i>p</i> &lt; 0.001) and had a shorter mean surgical time (25.3 ± 3&#xa0;min vs. 31.5 ± 4&#xa0;min; <i>p</i> &lt; 0.001). Pain scores were also lower in Group M (<i>p</i> = 0.01). These findings demonstrate that cisatracurium effectively induces neuromuscular block (NMB) and improves surgical conditions, resulting in lower postoperative pain scores in cats undergoing femoral fracture repair.</p>

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Evaluation of the effects of a single bolus of cisatracurium as part of an anesthetic protocol in cats undergoing orthopedic surgery

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月31日

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  • Claudia Interlandi,
  • Marco Tabbì,
  • Nicola Iannelli,
  • Diego Iannelli,
  • Giuseppe Barillaro,
  • Viola Zappone,
  • Simona Di Pietro,
  • Francesco Macrì

摘要

Non-depolarizing neuromuscular blocking agents (NMBAs) are commonly used in human anesthesia but remain uncommon in veterinary medicine. This study evaluated the effects of 0.5 mg/kg cisatracurium IV on muscle relaxation, cardiovascular variables and postoperative pain in cats undergoing orthopedic surgery. Twenty-four cats were randomly assigned to a control group (Group C) or a treatment group receiving cisatracurium (Group M) immediately after induction. Neuromuscular function was monitored using a calibrated train-of-four (TOF) device. Postoperative pain was assessed with the short form of the Glasgow Feline Composite Measure Pain Scale (CMPS-Feline). The mean time to suppression of muscle contraction was 2.6 ± 0.8 min, with peak suppression (90%) at 3.0 ± 0.7 min, a mean duration of 23.3 ± 4.4 min, and complete recovery at 27.3 ± 8.6 min. Group M required lower sevoflurane concentrations to maintain anesthesia compared to Group C (p < 0.001) and had a shorter mean surgical time (25.3 ± 3 min vs. 31.5 ± 4 min; p < 0.001). Pain scores were also lower in Group M (p = 0.01). These findings demonstrate that cisatracurium effectively induces neuromuscular block (NMB) and improves surgical conditions, resulting in lower postoperative pain scores in cats undergoing femoral fracture repair.