Scholarlink

Background <p>Universal vaccine against <i>Streptococcus suis</i> (<i>S. suis</i>) remains a challenge due to the high number of serotypes/strains, the absence of cross-protection among them and the existence of different immune escape strategies. In this study, the immunomodulatory potential of live and inactivated porcine derived Bacillus Calmette-Guérin (dpB) in combination with specific immunogenic proteins <i>S. suis</i> is evaluated in murine model.</p> Results <p>Results revealed different immune responses depending on dpB formulation. Live-dpB administered intravenously induced consistent results with trained immunity, including elevated proinflammatory cytokines and enhanced phagocytosis activity, reflecting stronger innate immune activation. However, inactivated dpB administered intravenously twice, enhanced adaptive responses post-<i>S. suis</i> vaccination showing increased IFN-γ levels in plasma and higher spot forming units in splenic ELISpot assays.</p> Discussion <p>These findings suggest complementary roles for live and inactivated dpB in innate and adaptive immunity. This approach may represent an initial step towards improving vaccine efficacy against <i>S. suis</i>, combining targeted innate with adaptive immunity. Further research is needed to optimize combinations of immunomodulators with traditional <i>S. suis</i> antigens.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluation of trained immunity as a potential strategy for a universal Streptococcus suis vaccine using immunogenic proteins in a murine model 

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月2日

查看全文
  • Lidia Sánchez-Morales,
  • Leydis Zamora,
  • Marta Pérez-Sancho,
  • Teresa García-Seco,
  • Inmaculada Moreno,
  • Andrea Pérez-Domingo,
  • Marta Díaz-Frutos,
  • Sergio Ciordia,
  • Aránzazu Buendía,
  • María de los Ángeles Risalde,
  • Mercedes Domínguez,
  • Lucas Domínguez

摘要

Background

Universal vaccine against Streptococcus suis (S. suis) remains a challenge due to the high number of serotypes/strains, the absence of cross-protection among them and the existence of different immune escape strategies. In this study, the immunomodulatory potential of live and inactivated porcine derived Bacillus Calmette-Guérin (dpB) in combination with specific immunogenic proteins S. suis is evaluated in murine model.

Results

Results revealed different immune responses depending on dpB formulation. Live-dpB administered intravenously induced consistent results with trained immunity, including elevated proinflammatory cytokines and enhanced phagocytosis activity, reflecting stronger innate immune activation. However, inactivated dpB administered intravenously twice, enhanced adaptive responses post-S. suis vaccination showing increased IFN-γ levels in plasma and higher spot forming units in splenic ELISpot assays.

Discussion

These findings suggest complementary roles for live and inactivated dpB in innate and adaptive immunity. This approach may represent an initial step towards improving vaccine efficacy against S. suis, combining targeted innate with adaptive immunity. Further research is needed to optimize combinations of immunomodulators with traditional S. suis antigens.