Scholarlink

Background <p>Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease that significantly impairs quality of life. Nutritional interventions have gained attention as supportive therapeutic strategies. This study investigated the clinical efficacy and safety of a functional diet containing <i>Siraitia grosvenorii</i> residual extract by evaluating its effects on clinical symptoms and inflammatory markers in dogs with CAD using a self-controlled design.</p> Methods <p>A total of 32 dogs diagnosed with CAD were fed a standard diet for 12 weeks (control phase) followed by a functional diet for 12 weeks (treatment phase). Clinical assessments, including transepidermal water loss (TEWL), Canine Atopic Dermatitis Extent and Severity Index (CADESI-04), Pruritus Visual Analog Scale (PVAS), Owner Global Assessment of Treatment Efficacy (OGATE), and serum IgE levels were conducted at baseline and at 6-week intervals.</p> Results <p>TEWL, CADESI-04, and PVAS scores significantly improved during the treatment phase compared with the control phase (<i>p</i> = 0.0002, &lt; 0.0001, and &lt; 0.0001, respectively). No significant difference was observed in serum in serum IgE levels (<i>p</i> = 0.8046). The OGATE responses indicated 80.65% rate of owner-reported satisfaction.</p> Conclusions <p>The functional diet significantly improved the clinical signs of CAD and was well tolerated. These findings suggest that nutritional support with the Siraitia grosvenorii extract may be a beneficial adjunctive therapy for CAD.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinical evaluation of a functional diet containing Siraitia grosvenorii residual extract for atopic dermatitis in dogs: a self-controlled study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月5日

查看全文
  • Mi-Kyung Park,
  • Jihee Hong,
  • Woo Jae Cho,
  • Kun-Ho Song

摘要

Background

Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease that significantly impairs quality of life. Nutritional interventions have gained attention as supportive therapeutic strategies. This study investigated the clinical efficacy and safety of a functional diet containing Siraitia grosvenorii residual extract by evaluating its effects on clinical symptoms and inflammatory markers in dogs with CAD using a self-controlled design.

Methods

A total of 32 dogs diagnosed with CAD were fed a standard diet for 12 weeks (control phase) followed by a functional diet for 12 weeks (treatment phase). Clinical assessments, including transepidermal water loss (TEWL), Canine Atopic Dermatitis Extent and Severity Index (CADESI-04), Pruritus Visual Analog Scale (PVAS), Owner Global Assessment of Treatment Efficacy (OGATE), and serum IgE levels were conducted at baseline and at 6-week intervals.

Results

TEWL, CADESI-04, and PVAS scores significantly improved during the treatment phase compared with the control phase (p = 0.0002, < 0.0001, and < 0.0001, respectively). No significant difference was observed in serum in serum IgE levels (p = 0.8046). The OGATE responses indicated 80.65% rate of owner-reported satisfaction.

Conclusions

The functional diet significantly improved the clinical signs of CAD and was well tolerated. These findings suggest that nutritional support with the Siraitia grosvenorii extract may be a beneficial adjunctive therapy for CAD.