<p>Goat skin is considered a multifunctional organ with regulatory, sensory, and protective roles. Despite the goat’s economic importance and use as a model in biomedical research, it remains not given the suitable position in academic publications. This study aimed to investigate the expression of neuron-specific enolase (NSE) in the lips and ear pinnae of goats, revealing its considerable location among several sensory and structural components using immunohistochemical techniques. Also, we identified a new structure in different locations of the skin of the goat, referred to as the goat corpuscle. In the lip, NSE was strongly expressed in Ruffini corpuscles, goat corpuscles located in the skin and mucosa, and Merkel cells present in the stratum basale of the epidermis and hair follicles. NSE expression was also found in large nerves among skeletal muscle fibers, near sweat glands, sebaceous glands, and in the superficial layers of the dermis, where free nerve endings were directed. Vascular elements, including arteries, veins, and lymphatic vessels, exhibited NSE positivity in their endothelial and smooth muscle layers. Additionally, NSE was present in myoepithelial cells surrounding sweat and salivary gland secretory end pieces, fibroblasts, and telocytes in the connective tissue. In the ear, NSE was detected in Ruffini corpuscles, goat corpuscles, and a range of nerve fibers around cartilage and blood vessels. NSE expression was also observed in fibroblasts, chondroblasts, and telocytes in the cartilage and dermal tissues. This detailed mapping of NSE distribution provides new insights into its role in sensory and structural components, revealing its extensive involvement in the tissues.</p> Graphical abstract <p>Immunohistochemical localization of NSE key observations in goat lip and ear pinna: A: Ruffini corpuscle (RC) near the hair follicle (H) and near the sebaceous gland (Sb). B: goat corpuscle in subepithelial position skin (white arrow), C: Merkel cell neurite complex (white arrowheads). D: Nerves (black arrows) nearly surrounded the sinus hair (H) from all sides. E: telocyte (yellow arrow) with long telopods (black arrowheads) near the sweat gland (Sw). F: Cartilage related cells as in fibroblast (blue arrowheads) in the perichondrium, chondroblast (black arrowhead), and peripherally located chondrocytes (red arrowheads). (A,B and C scale bar=100 μm; D scale bar=200 μm; E and F scale bar=50 μm)</p> <p></p>