Scholarlink

Objectives <p><i>Trichomonas gallinae</i>, a protozoan parasite, is responsible for avian trichomoniasis, leading to significant morbidity and mortality, particularly among juvenile pigeons. Although metronidazole is the standard treatment, its potential for inducing resistance has prompted exploration of herbal extracts as alternative therapeutic options. This study aims to compare metronidazole’s antitrichomonal effects with oak (<i>Quercus infectoria</i>) extracts and carob (<i>Ceratonia siliqua</i>) on <i>T. gallinae in vitro</i>.</p> Methods <p><i>T. gallinae</i> samples were collected from infected pigeons. For the in vitro study, multiwell plates were used with different concentrations (5, 10, 25, 50, and 100&#xa0;µg/mL).</p> Results <p>The minimum inhibitory concentration (MIC) after 24&#xa0;hr for <i>Q. infectoria</i> was 25&#xa0;µg/mL, while for <i>C. siliqua</i> it was 50&#xa0;µg/mL. In comparison, the MIC of metronidazole was also found to be 50&#xa0;µg/mL.</p> Conclusions <p>Findings suggest that <i>Q. infectoria</i> and <i>C. siliqua</i> extracts exhibit potent antitrichomonal activity, comparable to metronidazole, in inhibiting <i>T. gallinae</i> trophozoite growth in vitro, making them viable natural alternatives.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative in vitro assessment of oak (Quercus infectoria) and Carob (Ceratonia siliqua) extracts as natural alternatives to metronidazole against Trichomonas gallinae

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月14日

查看全文
  • Bahaa Ibrahim Saeed,
  • Farnaz Malekifard,
  • Mohammad Yakhchali

摘要

Objectives

Trichomonas gallinae, a protozoan parasite, is responsible for avian trichomoniasis, leading to significant morbidity and mortality, particularly among juvenile pigeons. Although metronidazole is the standard treatment, its potential for inducing resistance has prompted exploration of herbal extracts as alternative therapeutic options. This study aims to compare metronidazole’s antitrichomonal effects with oak (Quercus infectoria) extracts and carob (Ceratonia siliqua) on T. gallinae in vitro.

Methods

T. gallinae samples were collected from infected pigeons. For the in vitro study, multiwell plates were used with different concentrations (5, 10, 25, 50, and 100 µg/mL).

Results

The minimum inhibitory concentration (MIC) after 24 hr for Q. infectoria was 25 µg/mL, while for C. siliqua it was 50 µg/mL. In comparison, the MIC of metronidazole was also found to be 50 µg/mL.

Conclusions

Findings suggest that Q. infectoria and C. siliqua extracts exhibit potent antitrichomonal activity, comparable to metronidazole, in inhibiting T. gallinae trophozoite growth in vitro, making them viable natural alternatives.