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Background <p>Maternal diabetes and obesity are established risk factors for adverse offspring health. Emerging evidence suggests that these fetal programming effects vary by sex, yet it remains unclear whether these factors independently or interactively influence early brain development.</p> Methods <p>This prospective study included 1,965 infants from six international cohorts. Infant MRI was used to derive subcortical volumes (thalamus, amygdala, hippocampus, pallidum, putamen, caudate). ComBat harmonization was applied. Multiple linear regression tested main and interaction effects of maternal obesity, maternal diabetes, and sex, controlling for covariates with false discovery rate (FDR) corrections.</p> Results <p>Of the sample, 46% were female (<i>N</i> = 909), 9% were exposed to maternal diabetes (<i>N</i> = 172), 22% to maternal obesity (<i>N</i> = 386), and 3% to both (<i>N</i> = 61). MRI scans were performed at 25.9 ± 18.8&#xa0;days. Maternal diabetes was associated with smaller thalamic volume (standardized β = -0.09, 95%CI –0.16 to -0.01, FDR <i>P</i> = 0.020), but this association was attenuated after adjusting for maternal obesity. Maternal obesity was associated with smaller hippocampal (standardized β = -0.13, 95%CI -0.21 to –0.05, FDR <i>P</i> = 0.009) and thalamic volumes (standardized β = -0.09, 95%CI -0.14 to –0.03, FDR <i>P</i> = 0.007).</p> <p>Sex-specific associations were observed. In females, maternal obesity was associated with smaller hippocampal (standardized β = -0.24, 95%CI -0.36 to -0.13, FDR <i>P</i> &lt; 0.001) and amygdala volumes (standardized β = -0.18, 95% CI = -0.30 to –0.06, FDR <i>P</i> = 0.016). A three-way interaction (diabetes x obesity x sex) was observed for thalamus volume (standardized β = -0.50, 95%CI -0.81 to -0.18, FDR <i>P</i> = 0.017). In males, combined exposure had lower thalamic volume compared to those with one or neither exposure (all <i>Ps</i> &lt; 0.05). In females, maternal obesity (standardized β = -0.12, 95%CI -0.20 to –0.04, FDR <i>P</i> = 0.015) and diabetes (standardized β = -0.16, 95%CI -0.30 to –0.02, FDR <i>P</i> = 0.042) showed independent associations with thalamic volume, without a significant interaction (standardized β = 0.23, 95%CI -0.01 to 0.46, FDR <i>P</i> = 0.092).</p> Conclusions <p>Maternal obesity shows stronger associations with infant subcortical volumes than maternal diabetes. It is associated with smaller hippocampal and amygdala volumes in females, while combined exposure to maternal diabetes and obesity is associated with smaller thalamic volumes in males. These findings highlight the role of maternal metabolic health and infant sex in early neurodevelopment.</p>

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Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月16日

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  • Ann M. Alex,
  • Jerod M. Rasmussen,
  • Jetro J. Tuulari,
  • Julie Nihouarn Sigurdardottir,
  • Claudia Buss,
  • Kirsten A. Donald,
  • A. David Edwards,
  • Sonja Entringer,
  • John H. Gilmore,
  • Nynke A. Groenewold,
  • Hasse Karlsson,
  • Linnea Karlsson,
  • Katherine E. Lawrence,
  • Inka Mattila,
  • Dan J. Stein,
  • Martin Styner,
  • Paul M. Thompson,
  • Pathik D. Wadhwa,
  • Heather J. Zar,
  • Xi Zhu,
  • Gustavo de los Campos,
  • Rebecca C. Knickmeyer,
  • Shan Luo

摘要

Background

Maternal diabetes and obesity are established risk factors for adverse offspring health. Emerging evidence suggests that these fetal programming effects vary by sex, yet it remains unclear whether these factors independently or interactively influence early brain development.

Methods

This prospective study included 1,965 infants from six international cohorts. Infant MRI was used to derive subcortical volumes (thalamus, amygdala, hippocampus, pallidum, putamen, caudate). ComBat harmonization was applied. Multiple linear regression tested main and interaction effects of maternal obesity, maternal diabetes, and sex, controlling for covariates with false discovery rate (FDR) corrections.

Results

Of the sample, 46% were female (N = 909), 9% were exposed to maternal diabetes (N = 172), 22% to maternal obesity (N = 386), and 3% to both (N = 61). MRI scans were performed at 25.9 ± 18.8 days. Maternal diabetes was associated with smaller thalamic volume (standardized β = -0.09, 95%CI –0.16 to -0.01, FDR P = 0.020), but this association was attenuated after adjusting for maternal obesity. Maternal obesity was associated with smaller hippocampal (standardized β = -0.13, 95%CI -0.21 to –0.05, FDR P = 0.009) and thalamic volumes (standardized β = -0.09, 95%CI -0.14 to –0.03, FDR P = 0.007).

Sex-specific associations were observed. In females, maternal obesity was associated with smaller hippocampal (standardized β = -0.24, 95%CI -0.36 to -0.13, FDR P < 0.001) and amygdala volumes (standardized β = -0.18, 95% CI = -0.30 to –0.06, FDR P = 0.016). A three-way interaction (diabetes x obesity x sex) was observed for thalamus volume (standardized β = -0.50, 95%CI -0.81 to -0.18, FDR P = 0.017). In males, combined exposure had lower thalamic volume compared to those with one or neither exposure (all Ps < 0.05). In females, maternal obesity (standardized β = -0.12, 95%CI -0.20 to –0.04, FDR P = 0.015) and diabetes (standardized β = -0.16, 95%CI -0.30 to –0.02, FDR P = 0.042) showed independent associations with thalamic volume, without a significant interaction (standardized β = 0.23, 95%CI -0.01 to 0.46, FDR P = 0.092).

Conclusions

Maternal obesity shows stronger associations with infant subcortical volumes than maternal diabetes. It is associated with smaller hippocampal and amygdala volumes in females, while combined exposure to maternal diabetes and obesity is associated with smaller thalamic volumes in males. These findings highlight the role of maternal metabolic health and infant sex in early neurodevelopment.