Scholarlink

Background <p>Respiratory syncytial virus (RSV) causes recurrent infections throughout life. Yet, the form and durability of antibody-mediated protection induced by infection remained poorly understood.</p> Methods <p>We conducted a longitudinal cohort study in Taizhou City, China. Participant age distribution approximately reflected the age structure of population in Taizhou. Blood samples were collected at baseline (March 12, 2023) and four follow-up visits (May 7–26, 2023, August 13–23, 2023, November 12, 2023, and June 2–3, 2024). Serum-specific RSV pre-fusion F (PreF) protein antibody titres were measured for all samples, and neutralising antibodies against RSV strain A2 and RSV strain B were assessed in a subset. Using a Bayesian inference framework and reversible-jump Markov Chain Monte Carlo, we recovered individual infection histories, estimated population-level RSV incidence, and characterised antibody dynamics from longitudinal PreF titres. We also estimated the correlates of protection (COP) by quantifying the relationship between PreF antibody titres and infection risk.</p> Results <p>A total of 508 individuals were included. Over the study period, two RSV epidemic waves were observed: the first wave between May and November 2023 and the second from February to May 2024. We estimated seasonal RSV infection rates of 4–7% in the community-based population. Post-infection immunity responses were most robust in young children ≤ 5&#xa0;years and weakest in adults ≥ 75&#xa0;years, with peak fold rises in antibody titres of 29.4 and 5.4, respectively. The post-infection antibody titres declined substantially, with fourfold rises sustained for an average of 128&#xa0;days (95% credible interval of 21–281). The probability of protection given exposure increased with higher PreF titres across all age groups. However, the predictive performance of PreF titres as a COP varied markedly by age: titres strongly predicted protection in young children but showed weaker discrimination in older children and adults, and minimal predictive value in the oldest adults.</p> Conclusions <p>These results revealed age-related differences in the durability and protective value of natural infection–elicited RSV PreF antibody responses, emphasising the importance of age-specific prevention strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月9日

查看全文
  • Qiang Wang,
  • David Hodgson,
  • Bo Zheng,
  • Hongbiao Liang,
  • Suyi Zhang,
  • Jiahao Xu,
  • Kathy Leung,
  • Adam Kucharski,
  • Haijiang Lin,
  • Weibing Wang

摘要

Background

Respiratory syncytial virus (RSV) causes recurrent infections throughout life. Yet, the form and durability of antibody-mediated protection induced by infection remained poorly understood.

Methods

We conducted a longitudinal cohort study in Taizhou City, China. Participant age distribution approximately reflected the age structure of population in Taizhou. Blood samples were collected at baseline (March 12, 2023) and four follow-up visits (May 7–26, 2023, August 13–23, 2023, November 12, 2023, and June 2–3, 2024). Serum-specific RSV pre-fusion F (PreF) protein antibody titres were measured for all samples, and neutralising antibodies against RSV strain A2 and RSV strain B were assessed in a subset. Using a Bayesian inference framework and reversible-jump Markov Chain Monte Carlo, we recovered individual infection histories, estimated population-level RSV incidence, and characterised antibody dynamics from longitudinal PreF titres. We also estimated the correlates of protection (COP) by quantifying the relationship between PreF antibody titres and infection risk.

Results

A total of 508 individuals were included. Over the study period, two RSV epidemic waves were observed: the first wave between May and November 2023 and the second from February to May 2024. We estimated seasonal RSV infection rates of 4–7% in the community-based population. Post-infection immunity responses were most robust in young children ≤ 5 years and weakest in adults ≥ 75 years, with peak fold rises in antibody titres of 29.4 and 5.4, respectively. The post-infection antibody titres declined substantially, with fourfold rises sustained for an average of 128 days (95% credible interval of 21–281). The probability of protection given exposure increased with higher PreF titres across all age groups. However, the predictive performance of PreF titres as a COP varied markedly by age: titres strongly predicted protection in young children but showed weaker discrimination in older children and adults, and minimal predictive value in the oldest adults.

Conclusions

These results revealed age-related differences in the durability and protective value of natural infection–elicited RSV PreF antibody responses, emphasising the importance of age-specific prevention strategies.