Scholarlink

Background <p>Whole food plant-based diets exert anti-inflammatory properties and have been associated with clinical improvements in patients with autoimmune disorders. The underlying mechanisms remain poorly understood and functional insights into nutrient-host physiology cross-talks are urgently warranted. The present study investigated the effects of an isocaloric 8-week vegan diet (VD) intervention on whole blood count parameters and lymphoid composition in comparison to a meat-rich diet (MD).</p> Methods <p>We conducted a two-arm, monocentric randomized-controlled trial with healthy adults who were randomly allocated to either a MD or a VD for 8 consecutive&#xa0;weeks. Foods of animal origin were not permitted on the VD, whereas participants in the MD group were asked to consume at least 150 g of meat per day.</p> Results <p>Fifty-seven participants completed the study. At week 8, significant between-group differences were found for the white blood cell count (median (interquartile range): 5.17 (1.62) *10<sup>3</sup>/µL in the VD group vs. 5.39 (1.92) *10<sup>3</sup>/µL in the MD group, <i>p</i> = 0.029) and the lymphocyte count (1.80 ± 0.53 *10<sup>3</sup>/µL in the VD group vs. 2.06 (0.74) *10<sup>3</sup>/µL&#xa0;in the MD group, <i>p</i> = 0.049). This difference was driven by an increase in lymphocytes in MD group participants over the course of the study. Median change scores in platelets differed between VD and MD participants (− 21 (− 31) *10<sup>3</sup>/µL in the VD group vs. − 1.21 ± 28.37 *10<sup>3</sup>/µL in the MD group, <i>p</i> = 0.035) and so did the neutrophil change scores (− 0.17 (− 0.31) *10<sup>3</sup>/µL vs. 0.13 (0.50) *10<sup>3</sup>/µL, <i>p</i> = 0.034). Mixed models for repeated measures with a time-diet interaction as a fixed effect suggested that changes in white blood cells were driven by the diet factor alone (contrast: − 0.50 (95% CI: − 0.99–(− 0.01)), <i>p</i> = 0.046). Immunophenotyping results suggested significant between-group differences in CD3<sup>+</sup> and CD8<sup>+</sup> T-cells, and CD19<sup>+</sup> B-cells after 8 weeks. CD19<sup>+</sup> B-cells decreased significantly in the vegan group (214.77 ± 96.64 at baseline vs. 171.56 (102.73) cells/µL at week 8).</p> Conclusions <p>The present study suggests that a VD, in comparison to a MD, reduces the number of various immune cells even in healthy individuals. A VD may thus exert anti-inflammatory properties.</p> Trial registration <p>Registered at Deutsches Register Klinischer Studien: DRKS00031541.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月10日

查看全文
  • Julian Herter,
  • Frieda Stübing,
  • Volker Lüth,
  • Ann-Kathrin Lederer,
  • Ulrich Salzer,
  • Ana Cecilia Venhoff,
  • Bettina Sehnert,
  • Luciana Hannibal,
  • Reinhard Edmund Voll,
  • Roman Huber,
  • Maximilian Andreas Storz

摘要

Background

Whole food plant-based diets exert anti-inflammatory properties and have been associated with clinical improvements in patients with autoimmune disorders. The underlying mechanisms remain poorly understood and functional insights into nutrient-host physiology cross-talks are urgently warranted. The present study investigated the effects of an isocaloric 8-week vegan diet (VD) intervention on whole blood count parameters and lymphoid composition in comparison to a meat-rich diet (MD).

Methods

We conducted a two-arm, monocentric randomized-controlled trial with healthy adults who were randomly allocated to either a MD or a VD for 8 consecutive weeks. Foods of animal origin were not permitted on the VD, whereas participants in the MD group were asked to consume at least 150 g of meat per day.

Results

Fifty-seven participants completed the study. At week 8, significant between-group differences were found for the white blood cell count (median (interquartile range): 5.17 (1.62) *103/µL in the VD group vs. 5.39 (1.92) *103/µL in the MD group, p = 0.029) and the lymphocyte count (1.80 ± 0.53 *103/µL in the VD group vs. 2.06 (0.74) *103/µL in the MD group, p = 0.049). This difference was driven by an increase in lymphocytes in MD group participants over the course of the study. Median change scores in platelets differed between VD and MD participants (− 21 (− 31) *103/µL in the VD group vs. − 1.21 ± 28.37 *103/µL in the MD group, p = 0.035) and so did the neutrophil change scores (− 0.17 (− 0.31) *103/µL vs. 0.13 (0.50) *103/µL, p = 0.034). Mixed models for repeated measures with a time-diet interaction as a fixed effect suggested that changes in white blood cells were driven by the diet factor alone (contrast: − 0.50 (95% CI: − 0.99–(− 0.01)), p = 0.046). Immunophenotyping results suggested significant between-group differences in CD3+ and CD8+ T-cells, and CD19+ B-cells after 8 weeks. CD19+ B-cells decreased significantly in the vegan group (214.77 ± 96.64 at baseline vs. 171.56 (102.73) cells/µL at week 8).

Conclusions

The present study suggests that a VD, in comparison to a MD, reduces the number of various immune cells even in healthy individuals. A VD may thus exert anti-inflammatory properties.

Trial registration

Registered at Deutsches Register Klinischer Studien: DRKS00031541.