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Background <p>Patients with acute coronary syndrome (ACS) remain at high risk for recurrent adverse cardiovascular events after discharge. Patient adherence to secondary prevention is poor. This study proposes a follow-up center-based secondary prevention program to assess whether a structured cardiologist-led follow-up and reexamination protocol influences ACS patient prognosis.</p> Methods <p>A total of 9,534 ACS patients undergoing coronary angiography were retrospectively included and divided into a reexamination group (<i>n</i> = 6,804) and a non-reexamination group (<i>n</i> = 2,730) according to whether they were reexamined within one year or not. The patients were followed up after discharge for 3&#xa0;years, and clinical outcomes were recorded. The primary outcome was cardiac death.</p> Results <p>Reexamination within 12&#xa0;months was significantly associated with a reduced risk of cardiac death (adjusted hazard ratio [aHR], 0.58; 95% confidence interval [CI], 0.44–0.75) at 3&#xa0;years after ACS. Among patients who underwent reexamination, the risk of cardiac death was 50% lower (aHR, 0.50; 95% CI, 0.35–0.70) and 63% lower (aHR, 0.37; 95% CI, 0.20–0.67) in the high-frequency (more than or equal to 2 times within one year) and long-term (continued reexamination after the first year of follow-up) reexamination groups, respectively. Similar results were observed after propensity score matching analysis.</p> Conclusions <p>Participation in a structured follow-up and reexamination programme significantly reduces the risk of cardiac death among ACS survivors. Establishing a follow-up center could be of great significance in improving patient prognoses.</p>

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The effect of follow-up reexamination on the long-term prognosis of patients with acute coronary syndrome undergoing coronary angiography

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月22日

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  • Chao Wang,
  • Lina Cui,
  • Xianqin Ma,
  • Meng Sun,
  • Yulin Wang,
  • Fuhong Dong,
  • Chen Zhao,
  • Xueqin Tian,
  • Yini Wang,
  • Haihong Zhang,
  • Tianhui Cao,
  • Xinyu Hou,
  • Jian Wu,
  • Sining Hu,
  • Jiannan Dai,
  • Duolao Wang,
  • Haibo Jia,
  • Bo Yu

摘要

Background

Patients with acute coronary syndrome (ACS) remain at high risk for recurrent adverse cardiovascular events after discharge. Patient adherence to secondary prevention is poor. This study proposes a follow-up center-based secondary prevention program to assess whether a structured cardiologist-led follow-up and reexamination protocol influences ACS patient prognosis.

Methods

A total of 9,534 ACS patients undergoing coronary angiography were retrospectively included and divided into a reexamination group (n = 6,804) and a non-reexamination group (n = 2,730) according to whether they were reexamined within one year or not. The patients were followed up after discharge for 3 years, and clinical outcomes were recorded. The primary outcome was cardiac death.

Results

Reexamination within 12 months was significantly associated with a reduced risk of cardiac death (adjusted hazard ratio [aHR], 0.58; 95% confidence interval [CI], 0.44–0.75) at 3 years after ACS. Among patients who underwent reexamination, the risk of cardiac death was 50% lower (aHR, 0.50; 95% CI, 0.35–0.70) and 63% lower (aHR, 0.37; 95% CI, 0.20–0.67) in the high-frequency (more than or equal to 2 times within one year) and long-term (continued reexamination after the first year of follow-up) reexamination groups, respectively. Similar results were observed after propensity score matching analysis.

Conclusions

Participation in a structured follow-up and reexamination programme significantly reduces the risk of cardiac death among ACS survivors. Establishing a follow-up center could be of great significance in improving patient prognoses.