Scholarlink

Background <p>The relationship between sleep quality and Alzheimer's disease (AD), and its interaction with genetic susceptibility, remains unclear. Our study explores the complex association between sleep quality and AD risk, focusing on the moderating role of the <i>APOE</i> ε4 allele.</p> Methods <p>Linear regression models, linear mixed-effects models, and Cox proportional hazard models were conducted in 321,905 non-demented participants from UK Biobank (UKB, mean age = 56.49, mean follow-up: 12.3&#xa0;years) and 1,598 non-demented participants (mean age = 73.19, mean follow-up: 3.90&#xa0;years) from Alzheimer's Disease Neuroimaging Initiative (ADNI). The interaction terms of sleep by <i>APOE</i> ε4 status were added in all analyses and stratified analyses were further performed. Proteomic and bioinformatic analyses were conducted to explore the biological mechanisms by which sleep and its interaction with <i>APOE</i> ε4 influence the development of AD.</p> Results <p>Poor sleep quality was significantly associated with worse cognition, faster hippocampal atrophy, and increased AD risk (HR = 1.05 in UKB and HR = 1.37 in ADNI). Notably, these associations were intensified in <i>APOE</i> ε4 carriers. Proteomic analyses identified eleven proteins linked to both poor sleep and AD risk (<i>P</i> &lt; 1.72 × 10<sup>–5</sup>). These proteins were enriched mainly in inflammatory and metabolic pathways. Growth differentiation factor 15 was identified as the bridge linking poor sleep and AD risk specifically in <i>APOE</i> ε4 carriers.</p> Conclusions <p>Poor sleep is associated with increased risk of AD, possibly by dysregulating peripheral inflammatory responses and metabolic pathways. The interaction between poor sleep and <i>APOE</i> ε4 may further enhance AD risk. Future studies are warranted to test whether this interaction was driven by neuroinflammation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sleep quality, APOE ε4, and Alzheimer’s disease: associations from two prospective cohort studies and mechanisms by plasma proteomic analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月6日

查看全文
  • Liang-Yu Huang,
  • Lan Tan,
  • Chen-Chen Tan,
  • Xin-Yu Zhang,
  • Xu Lin,
  • Juan-Juan Zou,
  • Yu-Jing Lin,
  • Yu-Ying Zhang,
  • Quan Hao,
  • Zi-Qi Zhang,
  • Wei Xu

摘要

Background

The relationship between sleep quality and Alzheimer's disease (AD), and its interaction with genetic susceptibility, remains unclear. Our study explores the complex association between sleep quality and AD risk, focusing on the moderating role of the APOE ε4 allele.

Methods

Linear regression models, linear mixed-effects models, and Cox proportional hazard models were conducted in 321,905 non-demented participants from UK Biobank (UKB, mean age = 56.49, mean follow-up: 12.3 years) and 1,598 non-demented participants (mean age = 73.19, mean follow-up: 3.90 years) from Alzheimer's Disease Neuroimaging Initiative (ADNI). The interaction terms of sleep by APOE ε4 status were added in all analyses and stratified analyses were further performed. Proteomic and bioinformatic analyses were conducted to explore the biological mechanisms by which sleep and its interaction with APOE ε4 influence the development of AD.

Results

Poor sleep quality was significantly associated with worse cognition, faster hippocampal atrophy, and increased AD risk (HR = 1.05 in UKB and HR = 1.37 in ADNI). Notably, these associations were intensified in APOE ε4 carriers. Proteomic analyses identified eleven proteins linked to both poor sleep and AD risk (P < 1.72 × 10–5). These proteins were enriched mainly in inflammatory and metabolic pathways. Growth differentiation factor 15 was identified as the bridge linking poor sleep and AD risk specifically in APOE ε4 carriers.

Conclusions

Poor sleep is associated with increased risk of AD, possibly by dysregulating peripheral inflammatory responses and metabolic pathways. The interaction between poor sleep and APOE ε4 may further enhance AD risk. Future studies are warranted to test whether this interaction was driven by neuroinflammation.