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Background <p>To investigate the effects of increased weight-loading on body weight, body composition, fat mass distribution, physical activity and energy balance in individuals with obesity.</p> Methods <p>This single-centre non-blinded randomised controlled trial was conducted from August 1, 2021, through February 28, 2022. Adults with obesity class 1 (body mass index, BMI 30–35&#xa0;kg/m<sup>2</sup>) were assigned to wear either a heavy (high load; 11% of body weight, <i>n</i> = 28) or light (low load; 1% of body weight, <i>n</i> = 30) weight vest for 8&#xa0;h per day over 5&#xa0;weeks.</p> Results <p>High-load treatment reduced fat mass (mean difference − 2.60%; 95% CI − 3.79, − 1.41) and increased lean mass (mean difference 1.40%; 95% CI 0.37, 2.42), with no significant effect on body weight. Fat mass reductions were primarily observed in weight-loaded regions but not in the non-weight-bearing regions such as the arms. Waist circumference decreased (mean difference − 2.26%; 95% CI − 3.81, − 0.71) in the high-load group compared to the low-load group. Despite these beneficial changes, sedentary time was higher in the high-load group (mean difference 4.69%; 95% CI 0.98, 8.39) compared to the low-load group, while energy expenditure and energy intake remained unchanged.</p> Conclusions <p>Increased weight-loading reduced fat mass and increased lean mass, resulting in a healthier body composition. These effects were achieved despite no increase in physical activity. The fat mass-reducing effect was primarily seen in weight-loaded regions, implying local adaptation to the increased loading.</p> Trial registration <p>Registered at ClinicalTrials.gov (NCT04697238) in 2021.</p>

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Increased weight-load improves body composition by reducing fat mass and waist circumference, and by increasing lean mass in participants with obesity: a single-centre randomised controlled trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月30日

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  • Jakob Bellman,
  • Klaas Westerterp,
  • Loek Wouters,
  • Marit Johannesson,
  • Niklas Lundqvist,
  • Joel Kullberg,
  • Christel Larsson,
  • Mikael Gustafsson,
  • Stefan Pettersson,
  • Jonatan Fridolfsson,
  • Daniel Arvidsson,
  • Mats Börjesson,
  • Dan Curiac,
  • John-Olov Jansson,
  • Per-Anders Jansson,
  • Claes Ohlsson

摘要

Background

To investigate the effects of increased weight-loading on body weight, body composition, fat mass distribution, physical activity and energy balance in individuals with obesity.

Methods

This single-centre non-blinded randomised controlled trial was conducted from August 1, 2021, through February 28, 2022. Adults with obesity class 1 (body mass index, BMI 30–35 kg/m2) were assigned to wear either a heavy (high load; 11% of body weight, n = 28) or light (low load; 1% of body weight, n = 30) weight vest for 8 h per day over 5 weeks.

Results

High-load treatment reduced fat mass (mean difference − 2.60%; 95% CI − 3.79, − 1.41) and increased lean mass (mean difference 1.40%; 95% CI 0.37, 2.42), with no significant effect on body weight. Fat mass reductions were primarily observed in weight-loaded regions but not in the non-weight-bearing regions such as the arms. Waist circumference decreased (mean difference − 2.26%; 95% CI − 3.81, − 0.71) in the high-load group compared to the low-load group. Despite these beneficial changes, sedentary time was higher in the high-load group (mean difference 4.69%; 95% CI 0.98, 8.39) compared to the low-load group, while energy expenditure and energy intake remained unchanged.

Conclusions

Increased weight-loading reduced fat mass and increased lean mass, resulting in a healthier body composition. These effects were achieved despite no increase in physical activity. The fat mass-reducing effect was primarily seen in weight-loaded regions, implying local adaptation to the increased loading.

Trial registration

Registered at ClinicalTrials.gov (NCT04697238) in 2021.