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<p>Iron is indispensable to most lifeforms, underpinning a myriad of physiological processes. Dysregulation of iron homeostasis underlies a broad spectrum of biological phenomena and pathological conditions. Notably, excessive iron overload acts as a key driver of ferroptosis, a unique form of regulated cell death. Consequently, through the lens of ferrology, targeted modulation of iron balance and ferroptosis has emerged as a compelling avenue for the prevention and treatment of major diseases. Herein, we review the molecular mechanisms governing iron homeostasis, the roles of iron metabolism disorders and ferroptosis in disease pathogenesis, and the latest breakthroughs in iron-regulated therapeutic agents.</p>

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Iron metabolism and ferroptosis in human health and disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月22日

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  • Meijuan Zhong,
  • Yuandi Wang,
  • Junxia Min,
  • Fudi Wang

摘要

Iron is indispensable to most lifeforms, underpinning a myriad of physiological processes. Dysregulation of iron homeostasis underlies a broad spectrum of biological phenomena and pathological conditions. Notably, excessive iron overload acts as a key driver of ferroptosis, a unique form of regulated cell death. Consequently, through the lens of ferrology, targeted modulation of iron balance and ferroptosis has emerged as a compelling avenue for the prevention and treatment of major diseases. Herein, we review the molecular mechanisms governing iron homeostasis, the roles of iron metabolism disorders and ferroptosis in disease pathogenesis, and the latest breakthroughs in iron-regulated therapeutic agents.