Background <p>Digital health is becoming central to diabetes care, yet the preparedness of the nursing workforce remains uneven. This study examined digital health readiness, technology acceptance, and perceived organisational readiness for nurse-led telehealth and remote glucose monitoring among endocrinology nurses in China. It also explored individual and organisational factors linked to readiness and behavioural intention to use these tools.</p> Methods <p>We conducted a multi-centre cross-sectional study between October 2024 and January 2025 in five public general hospitals in Shanxi Province, China. Eligible endocrinology and diabetes nurses completed a structured questionnaire on demographic and professional characteristics, exposure to digital tools, digital health readiness, Technology Acceptance Model constructs, and organisational readiness. We also undertook pre-specified exploratory subgroup comparisons by recent training, age, and implementation setting. Quantitative data were analysed using descriptive statistics, correlations, subgroup comparisons, and multiple linear regression. Open-ended responses and semi-structured interviews were analysed thematically to explain the quantitative findings.</p> Results <p>A total of 230 nurses completed the survey. Overall digital health readiness was moderate to high. Nurses reported strong openness and motivation, but lower perceived organisational support and resources. Telephone follow-up and WeChat-based communication were common, whereas video consultations and structured remote monitoring were less common. Nurses who had received recent digital health training reported broader exposure to digital tools and more favourable readiness and intention patterns than those without training. Perceived usefulness was the strongest correlate of behavioural intention, followed by perceived ease of use, digital readiness, and organisational readiness. Qualitative findings highlighted limited structured training, the “invisible” nature of digital workload, and the importance of leadership and a shared implementation vision.</p> Conclusions <p>In this sample, endocrinology nurses in Chinese general hospitals showed generally positive attitudes towards nurse-led digital care, but wider adoption appeared to be constrained by uneven exposure to advanced tools and only moderate organisational readiness. Efforts to strengthen digital endocrine care should focus on practical training, usable systems, and organisational support that recognises digital work as part of routine nursing care.</p>