Background <p>Patients with advanced cancer and their caregivers face significant psychosocial challenges, including distress, existential crises, and social isolation. Hispanic/Latino (H/L) communities experience disproportionate health disparities, exacerbating these challenges. Limited access to psychosocial care due to barriers, such as transportation and socioeconomic constraints, is especially evident among patients living in rural areas of Puerto Rico, where access to services is more restricted compared to metropolitan zones. These disparities underscore the need for culturally tailored interventions.</p> Objective <p>This study assesses the acceptability and refinement of the Caregivers-Patient Support for Latinx Coping with Advanced Cancer (CASA) intervention through the perspectives of healthcare providers and community partners. Using the RE-AIM framework, we examine the intervention’s Reach, Effectiveness, Adoption, Implementation, and Maintenance to enhance its impact and sustainability.</p> Methods <p>We conducted a qualitative study using Community-Based Participatory Research (CBPR), involving semi-structured interviews with 11 community partners and 10 healthcare providers actively involved in cancer care in Puerto Rico. Data were analyzed using a thematic content analysis within the RE-AIM framework to assess the feasibility, barriers, and facilitators of the intervention.</p> Results <p>Participants highlighted the relevance of the CASA intervention in addressing psychosocial needs, emphasizing the importance of integrating cultural values. Key facilitators included community engagement and telehealth, while barriers included patient resistance and logistical challenges. Recommendations included enhancing community partnerships and training.</p> Conclusion <p>The findings support CASA as a culturally tailored intervention that meets the unique needs of H/L patients and their caregivers. Community engagement and flexible implementation strategies are essential for its sustainability.</p>