Background <p>Nurses’ vitality, perceptions of decent work, and sickness presenteeism play a crucial role in patient safety and quality of care. However, these factors remain underexplored in the literature, underscoring the need for further research to examine the relationships among them. The study aims to examine the relationships between nurses’ perceptions of decent work, sickness presenteeism and work-related flow experiences.</p> Methods <p>The study used a cross-sectional, correlational design. A sample of 374 nurses employed at a university hospital in a province of Turkey was selected using convenience sampling. Data were collected using the Decent Work Scale, Sickness Presenteeism Scale-Nurse, The Work-Related Flow Inventory, on an Introductory Information Form. Pearson correlation analysis, multiple linear regression, independent samples t-test, and one-way ANOVA were conducted.</p> Results <p>A positive correlation was found between the total scores of the decent work scale and the work-related flow inventory. in addition, a weak significant correlation was found between the total scores of the sickness presenteeism scale-nurses and the work-related flow scale. According to the results of multiple linear regression analysis decent work significantly positively predicts work-related flow (β = 0.327, t = 6.84, <i>p</i> &lt; 0.001). On the other hand, sickness presenteeism significantly negatively predicts work-related flow (β = -0.211, t = -4.42, <i>p</i> &lt; 0.001).</p> Conclusion <p>Decent work was positively associated with concentration and engagement at work, while sickness presenteeism was negatively associated with work-related flow.</p> Clinical trial number <p>Not applicable.</p>