Background <p>Nurses play a crucial role in ensuring patient safety in a variety of contexts because they work in closer contact to their patients than any other group of healthcare workers. The first step to significantly improve and support patient safety in the clinical affiliations and future job environments of students is early instruction in undergraduate programs. As soon as they begin participating in relevant learning experiences in different setting, student nurses should be informed and carry the culture of safety with them.</p> Aim <p>This study aims to explore how nursing students from different backgrounds perceives patient safety.</p> Methods and materials <p>This qualitative study used semi-structured interview with a purposive sample of 9 Filipino and 9 Saudi undergraduate nursing students who are already exposed in different related learning experience settings. Interviews were transcribed verbatim and analyzed using thematic analysis. Ethical approval was obtained, and all participants provided their informed consent.</p> Results <p>Three key themes were identified: (1) Patient Safety as a Responsibility (2) Patient Safety as Preventing and (3) Following Safe Practices as Important Step to Patient Safety with two subthemes: (3.1) Being Vigilant and (3.2) Doing Safety Protocols.</p> Conclusion <p>Understanding these variations can help develop culturally sensitive safety measures in a variety of healthcare settings and guide more specialized teaching-learning strategies in the curriculum. Thus, future researchers must be done to explore culturally sensitive approaches in the nursing education.</p>