Background <p>Mothers who have given birth prematurely may need more information and support regarding infant care due to feelings of anxiety or unpreparedness. In this context, counseling, education, and follow-up services for mothers after discharge can be easily provided through tele-nursing applications.</p> Aim <p>To determine the effects of tele-nursing interventions on premature infants and their mothers.</p> Design <p>A systematic review.</p> Methods <p>Studies were included if they were randomized controlled or quasi-experimental trials published in English between 2014–2024 that examined telenursing interventions for premature infants or their mothers; studies using qualitative designs, observational methods, gray literature, or those involving term infants were excluded. PubMed, ScienceDirect, Scopus, Web of Science, Cochrane Library, CINAHL, and MEDLINE databases were searched, yielding a total of 492 studies. The Oxford Centre for Evidence-Based Medicine assessment tool was used to evaluate the quality of evidence. Accordingly, the included studies provided level 1–2 evidence. Due to heterogeneity in outcome measures and study designs, a narrative synthesis approach was used to summarize the findings.</p> Results <p>The review included 9 studies, consisting of 5 randomized controlled trials and 4 quasi-experimental studies. Improvements were observed in premature infants or their mothers in 8 of these studies. Tele-nursing was reported to reduce hospital readmissions for premature infants while increasing self-efficacy, attachment, awareness, and hope levels in their mothers. Additionally, a decrease in maternal stress and anxiety levels was among the findings reported in the studies.</p> Conclusion <p>Findings from the included studies suggest that, in settings with telenursing services, mothers may have improved access to health support after discharge, which can positively influence maternal and infant outcomes.</p> Clinical trial number <p>Not applicable.</p>