Background <p>Adherence to antiplatelet therapy is critical for preventing stent thrombosis and recurrent ischemic events following percutaneous coronary intervention (PCI). Despite its importance, non-adherence remains a global challenge, particularly in settings where sociocultural factors, health system limitations, and interprofessional practices intersect. Limited research has examined how nurses and other healthcare professionals perceive these challenges in the Saudi context.</p> Aim <p>To explore nurses’ and other healthcare professionals’ perspectives on barriers and enablers to antiplatelet medication adherence among post-PCI patients in Saudi Arabia.</p> Methods <p>A qualitative descriptive study was conducted in two tertiary cardiac centres in Riyadh. Using purposive sampling, 24 healthcare professionals (13 nurses, 8 cardiologists, 3 pharmacists) participated in semi-structured interviews. Data—reflecting healthcare providers’ perspectives—were analyzed thematically following Braun and Clarke’s framework. Analytical transparency and trustworthiness were ensured through triangulation, member checking, and reflexive journaling.</p> Results <p>Three overarching themes emerged: (1) patient- and family-related barriers, including misconceptions, cultural influence, and psychological factors; (2) healthcare system and communication challenges, including language barriers, fragmented continuity of care, and affordability issues; and (3) interprofessional collaboration and professional roles, highlighting nurses as trust builders, physicians as clinical anchors, and pharmacists as regimen simplifiers.</p> Conclusion <p>Findings reflect healthcare professionals’ perceptions of multifactorial barriers and enablers influencing adherence. Strengthening family-inclusive education, multilingual communication strategies, structured follow-up, and equitable access to medicines—supported by interprofessional collaboration—may enhance post-PCI outcomes in Saudi Arabia.</p> Clinical trial <p>Not applicable.</p>