Background <p>To determine the relationships between organizational commitment, job satisfaction, life satisfaction and demographic characteristics among nurses and to determine the predictors of organizational commitment.</p> Methods <p>The study was conducted as a cross-sectional study with 149 nurses in a public hospital between September and December 2024. Data were collected using the Descriptive Information Form, the Nurse Job Satisfaction Scale, the Organizational Commitment Scale, and the Life Satisfaction Scale. Descriptive statistics, independent sample t-test, one-way ANOVA test, Pearson correlation analysis and multiple regression analysis were applied in data analysis.</p> Results <p>Organizational commitment was found to be 3.17 ± 0.58, job satisfaction was 3.48 ± 0.70, and life satisfaction was 19.72 ± 6.87. Multiple regression analysis conducted to determine the predictors of organizational commitment revealed that nurses’ job satisfaction and age variables significantly predicted organizational commitment (<i>p</i> &lt; 0.05). The model explained 49.8% of the total variance in organizational commitment.</p> Conclusions <p>The results of this study highlight the importance of developing strategies and organizational interventions aimed at improving nurses’ job and life satisfaction and fostering organizational commitment. Interventions such as mentoring programs, stress management workshops, or flexible working hours may increase satisfaction and commitment levels.</p> Clinical trial number <p>Not applicable.</p>